食品防腐剤に関する研究-IX : タイロシン耐性株と感受性株の発育上の拮抗現象

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Experiments were made to elucidate the antagonism in growth between a tylosin-sensitive and its in vitro resistant strains of Bacillus subtilis. Results obtained may be summarized as follows: 1. In the mixed cultures of the sensitive and resistant cells either in Difco nutrient broth of pH 7.0 or in the tuna flesh infusion of pH 6.2 without tylosin, it was noted that the growth of resistant cells was inhibited when the mixing ratio was 1:1. The larger the ratio of sensitive cells, the more conspicuous the antagonism was (Tables 1 and 4). 2. In the Difco nutrient broth containing 0.2 ppm of tylosin, or in the tuna flesh infusion containing 1.6 ppm of the drug, nevertheless each level of tylosin was less than minimal inhibitory concentration for the growth of sensitive strain, the resistant organisms became predominant even in a mixing ratio 1:1 (Tables 2, 3, 5, 6 and 7).
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