Studies on the Food Poisoning Associated with Putrefaction of Marine Products-V:Influence of Trimethylamine and Trimethylamine Oxide Added to Histamine or "Saurine" upon Their Own Action Tested on the Contractility of Intestine and Uterus of Guinea Pigs

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The effect of trimethylamine (TMA) or trimethylamine oxide (TMAO) added to histamine, or "saurine" (an autonomic nervous poison like histamine recently isolated by the authors) was examined according to the contraction method (Magnus') using intestine or uterus of guinea pigs. Results obtained are as follows: 1. Using uterus, sometimes synergistic action of added TMA or TMAO to either histamine or "saurine" was observed to a certain extent, and sometimes no action was recorded in the same experiment. These irregular results might have been due mainly to the nature of contraction of uterus. However, even when positive synergism observed, the rate of increase in the action of his tamine or "saurine" was less than 10%. 2. In no case, synergistic action was observed in the experiment using intestine. Results obtained are summarized as follows. Concn. of histamine or "saurine" Range of concentration of test solution in M at which no synergistic action occurred histamine 2γ TMA 0.5×10-3-0.5×10-8M ?? 2γ TMAO 0.1×10-5-0.5×10-8M ?? 2γ histidine 1×10-4-1×10-7M "saurine" 0.3cc (1.5γ equivalent histamine) TMA 0.9×10-2-0.9×10-7M 0.4cc (2γ ?? )TMAO 0.9×10-2-0.9×10-7M 0.2cc (1γ ?? ) histidine 0.9×10-3-0.9×10-7M 3. From the results above described, both TMA and TMAO could not be considered to have any synergistic action upon histamine or "saurine".
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