生薬熱水抽出物の変異原活性抑制効果

概要

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Hot water extracts from 104 kinds of commercial Chinese crude drugs were tested for their desmutagenic activity on the mutagenicity of Trp-P-1. Desmutagenicity was determined by using the modified Ames bioassay method, with tester strain Salmonella typhimurium TA98, in the presence of rat-liver homogenate. Thirteen extracts were found to be desmutagenic. Three drugs exhibiting desmutagenicity, Rhei Rhizoma, Malloti Cortex and Gleditsiae Semen, were further tested for their desmutagenic and antimutagenic activities on several mutagens. All of the three extracts reduced the mutagenicity of the mutagens requiring S9 for metabolic activations, such as Trp-P-2, Aflatoxin B_1, 2-aminoanthracene and N-2-fluorenylacetamide, but did not show any effect on the mutagenicity of metabolically activated Trp-P-2 that is active without metabolic activation. None of the three extracts showed antimutagenic activity on other mutagens tested.
日本生薬学会の論文
1987-09-20