Transforming Growth Factor-.BETA.1 Expression and the Role of Angiotensin-converting Enzyme Inhibitor on Perianastomotic Intimal Hyperplasia in Polytetrafluoroethylene Graft Implanted in Rabbit Carotid Artery

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概要

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• The purpose of this study was to evaluate the relationship between intimal hyperplasia and transforming growth factor-β1 (TGF-β1) mRNA expression in synthetic arterial grafts and also to clarify the effect of angiotensin-converting enzyme inhibitor (ACEI) on perianastomotic intimal hyperplasia and TGF-β1 mRNA expression. Thirty New Zealand White rabbits were randomly divided into two groups (15 each); one group was administered Captopril 10 mg/kg/day per os as an ACE inhibitor, and the other group received on saline as a vehicle from 7 days prior to operation until the graft was harvest (1, 8, or 14 weeks). A 10-mm segment of an expanded polytetrafluoroethylene graft (3 mm in diameter) was implanted in the right common carotid artery of the rabbits;15 rabbits had by-pass grafting alone (Graft Alone group) and the other 15 rabbits had by-pass graft along with the ACEI (Graft plus ACEI group). The artery grafts were harvested. The intima to media height ratio (IMHR) and the TGF-β1 mRNA expression level in perianastomotic graft tissue by reverse transcription-polymerase chain reaction (RT-PCR). The IMHRs gradually increased from 1 to 14 weeks in both groups (vs. 1 wk in each group, p<0.05). The IMHRs of the Graft plus ACEI group were comparable to those of Graft Alone group at 1 week, but significantly lower at 8 and 14 weeks (vs. Graft Alone group, p<0.05). The TGF-β1 mRNA expression levels of the Graft plus ACEI group were clearly lower than those of the Graft Alone group at 1 and 8 weeks (vs. Graft Alone group, p<0.05), but similar at 14 weeks. TGF-β1 in the synthetic artery graft of the Graft Alone group was up-regulated as early as 1 week after the operation, when no definitive development of a quantifiable neointima was observed. The TGF-β1 mRNA expression of the Graft Alone group was highest at 8 weeks and lowest at 14 weeks (vs. 1 week, ∗p<0.05), but such time-dependent changes were not observed in the Graft plus ACEI group. The results indicated that ACEI reduced intimal hyperplasia in the grafts of the Graft plus ACEI group and also suppressed TGF-β1 mRNA expression in perianastomotic intimal hyperplasia tissues to the normal artery level. Perianastomotic intimal hyperplasia in synthetic arterial graft is considered to be related to TGF-β1, the expression of which is locally mediated by angiotensin II and, therefore, suppressed by ACEI.

• 久留米大学医学部 The Kurume Medical Journal 編集部の論文

著者

• JUNG Suk

  Department of Electronics Engineering, Korea University

• Whang Chung

  Department Of Physics Yonsei University

• Kim Young

  Department Of Agricultural Chemistry The University Of Tokyo

• Min Byung

  Department Of Animal Resource And Sciences Dankook University

• Lee Jae

  Department Of Acupuncture & Moxibustion College Of Oriental Medicine

• Shirouzu Kazuo

  Department Of Surgery Kurume University

• Koo Bum

  Department Of Surgery College Of Medicine Korea University Guro Hospital

• Son Gil

  Department Of Physical Therapy Youngnam College Of Science & Technology

• Choi Sang

  Department Of Agricultural Chemistry Gyeongsang National University

• Kim Jong

  Department Of Agricultural Bio-resources National Academy Of Agricultural Science Rural Development

• KIM Seung

  Department of Allergy and Clinical Immunology, Ajou University School of Medicine

• ISHIBASHI NOBUYA

  Department of Surgery, Kurume University School of Medicine

• KIM JONG

  Departments of Surgery Korea University College of Medicine

• UM JUN

  Departments of Surgery Korea University College of Medicine

• LEE JAE

  Departments of Surgery Korea University College of Medicine

• MIN BYUNG

  Departments of Surgery Korea University College of Medicine

• KIM YOUNG

  Departments of Pathology Korea University College of Medicine

• SHIROUZU KAZUO

  Department of Gastroenterology and Surgery, Kurume University School of Medicine

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