HBs抗原持続陽性者の病態と予後に関する研究 -年齢層別にみたHBs抗原自然陰性化傾向-

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Among the 832 HBsAg carriers who have been observed continuously (average observation periods 4.3 yrs.), 79 cases showed decrease of HBsAg titer under 2<SUP>6</SUP> by R-PHA. By critical analytical method "person year (P.Y.)", this tendency designated the highest peak at 41-44 years old (9.5% P.Y.) and the lowest peak at 31-34 year old (1.0% P.Y.).<BR>During the observation periods, 28 patients showed negative of HBsAg and 3 of them obtained anti-HBs. Decreased cases of HBsAg titer increased in elder patients and those showed anti-HBe positive during the observation period, and the result of the liver function tests was stable in those patlents.<BR>From these results, it is speculated that decrease of HBsAg titer may be ominous of HBsAg negative and the liver function tests are stable in this condition.
社団法人日本肝臓学会の論文