A long term follow-up study on hepatic diseases and their relative risk of death after blood transfusion.

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We performed a follow-up study about liver function tests and mortalities in male patients who had been transfused blood on operations of pulmonary tuberculosis.<BR>After 20 years examined there was no difference about HBV markers, ZTT showed significant higher values in blood transfusion group than in non-blood transfusion group, and ZTT and GPT levels significantly elevated in cases with post-transfused acute hepatitis than in nonblood transfusion group. Five cases in 6 died cases from hepatic diseases had history of posttransfused acute hepatitis.<BR>Relative risk of death caliculated by person-year method showed 13.3 of primary liver cancer and 4.0 of liver cirrhosis in blood transfusion group, and 25.9 of primary liver cancer and 12.1 of liver cirrhosis in cases with post-transfused acute hepatitis comparing with general male population in Japan. These results strongly suggested that blood transfusion cases, especially with post-transfused acute hepatitis, were high risk group of primary liver cancer and of liver cirrhosis.
社団法人日本肝臓学会の論文