:Retrospective study of patients with the history of blood transfusion

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A retrospective study of 51 blood-transfused patients with chronic liver diseases was carried out. All patients were followed up for long-term and diagnosis was made histologically. Of 51 patients, 14 (27.4%) were chronic persistent hepatitis (CPH), 21 (41.2%) were chronic active hepatis (CAH), 12 (23.5%) were liver cirrhosis (LC), 3 (5.9%) were hepatocellular carcinoma (HCC) and one (2.0%) was the other. In three cases with HCC, both HBs antigen and anti-HBs were negative. Peroid until the diagnosis was made after transfusion was 10.5±7.8 years (mean±SD) in CPH, 16.4±10.1 years in CAH, 18.8± 6.8 years in LC and 28.7 ± 1.5 years in HCC. In relation to these periods there were significant differences between CAH and CPH (p<0.05), LC and CPH (p<0.001) and HCC and CPH (p<0.001). Further more, there was significant difference (p<0.001) between that of LC and HCC. From these results it was suspected that the prognosis of transfused patients correlated with interval from blood transfusion.Histological findings showed no significant difference between patients with and without the history of post-transfusion liver injury (PTLI). Volume of transfusion also showed no correlation with occurrence of PTLI and with the prognosis of patients.These data indicate that blood-transfusion relates with progress to chronic hepatitis, however that other factors are required for development of chronic hepatitis into LC and HCC.
財団法人日本消化器病学会の論文

:Retrospective study of patients with the history of blood transfusion

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