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HBs-Ag, anti-HBs and liver function test were performed in 8917 of male subjects employed in Japanese National Railways. HBsAg was determined by R-PHA, anti-HBs by PHA and liver function was estimated by GOT, GPT, ALP, γ-GTP, ZTT, total protein, albumin and A/G ratio. These tests were examined at age of 25, 35, 40, 45 and 50 years old in 1981. Average positive rate of HBsAg showed 2.2% and increased at age of 35 and 40 years old. Positive rate of antiHBs revealed 23.9% and became higher with aging. Titers of HBsAg and anti-HBs decreased as age related manner. In HBsAg positive group, abnormal results of liver function tests were observed in groups at 25, 45 and 50 years old and in anti-HBs positive group abnormal liver functions increased in older groups.<BR>These data suggested that liver function disorders was affected not only by infection of HBV but also by aging.