The significance of CD5 B cells in various liver diseases.

概要

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Human B cell subpopulation, identifiable by the expression of the cell surface antigen CD5, was observed in peripheral blood lymphocytes obtained from patients with various liver diseases by dual two-color fluorescence flow cytometry.<BR>A significant increase in CD5 B cells was observed in patients with autoimmune hepatitis, chronic hepatitis and liver cirrhosis. In particular the increase was noted in patients with chronic hepatitis B, who were positive for HBeAg and in whom active inflammation was present. There was no significant difference in the CD5 B cell percentage between the group of controls and the group with acute hepatitis, primary biliary cirrhosis and asymptomatic HBV carrier state.<BR>In nonA nonB hepatitis, CD5 B cells were increased in patients with active hepatic inflammation, especially those who were autoantibody positive.<BR>These results suggested that CD5 B cells increased in patients who were in an inflammatory state of the liver, and played an important role in the worsening of hepatic injuries.
社団法人日本肝臓学会の論文