Metabolism of 3.BETA.,7.BETA.-dihydroxy-5.BETA.-cholan-24-oic acid in man: Change of the bile acid levels in the peripheral and portal blood, and the excretion into the bile, after the oral administration.:Change of the bile acid levels in the peripheral

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300mg of 3β, 7β-dihydroxy-5β-cholan-24-oic acid (3β, 7β-diOH) was oraly administered in three patients with choledocholithiasis in whom external biliary fistula was established.<BR>The change of serum level of 3β, 7β-diOH was different in three patients, and the peak levels in the peripheral blood were 27.5μg/ml, 3.7μg/ml and 94.5μg/ml, respectively. Appearance of ursodeoxycholic acid (UDCA) in the peripheral blood and the change of serum level after 3β, 7β-diOH administration was different in all patients.<BR>There was no relation between 3β, 7β-idOH levels in the peripheral and portal blood obtained at the same time from patients after the administration.<BR>Bile was collected by an hour through external biliary fistula during 24 hrs after the oral administration of 300mg 3β, 7β-diOH. 3β, 7β-diOH was not detected in the bile. However, UDCA clearly increased in the bile from three or four hrs after the 3β, 7β-diOH administration and it persisted for about 10 hrs. Other bile acid levels excreted into bile did not show significant changes.<BR>These results indicate that 3β, 7β-diOH is well absorbed from the intestine and are tranported via the portal blood to the liver. In the liver it undergoes transformation to 3α-hydroxy epimer and is excreted as UDCA into bile.
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