Immunohistochemical study of glutathione S-transferase (GST-.PI.) on hepatocellular carcinoma.

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Anionic form of glutathione S-transferase (GST-π) was purified in apparent homogenity from human placenta. The molecular weight of GST-π was 21, 000 by SDS-polyacrylamide gel electrophoresis and isoelectric point was 4.5 by analytical electrophocussing gel electrophoresis. According to ouchtrlony's method, antigenicity of GSY-π was identical with anionic GST from hepatocellular carcinoma and kidney. Immunohistochemical localization of GST-π in 30 cases of hepatocellular carcinoma revealed that positive staining was shown in 50% cases compared to Edmondson's grade I or II. It was interesting that hepatocytes around cancer tissue, not found out atypism, were stained intensively sometimes. Therefore, it is suggested that GST-π may be tumor marker for hepatocellular carcinoma. However, the investigation of GST-π rich hepatocytes around cancer tissue is necessary in connection with pre-cancerous lesion.
社団法人日本肝臓学会の論文