Biochemical analysis of accelerated liver regeneration with epidermal growth factor in rat with acute liver injury.

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概要

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• This study was performed to evaluate the stimulatory effect of epidermal growth factor (EGF) on liver regeneration in rat with massive hepatic necrosis induced by CCl<SUB>4</SUB>. Regarding number of EGF receptor and endogenous EGF level in the liver, in earlier time of liver injury both of them were significantly decreased. After administration of human EGF into those animals, great increase of exogenously given EGF was observed in liver tissues. Therefore, increase of DNA synthesis observed after injection of EGF might be due to a role of EGF incorporated into hepatocytes. In conclusion, EGF is extremely important peptide which stimulates strongly hepatic DNA synthesis and is applicable to the treatment of acute liver failure caused by massive hepatic necrosis.

• 社団法人 日本肝臓学会の論文

著者

• 村上 不二夫

  山口大学第1内科

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• Biochemical analysis of accelerated liver regeneration with epidermal growth factor in rat with acute liver injury.

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