ENZYMOLOGICAL STUDIES ON PREMALIGNANT LESIONS OF THE GASTRIC CANCER:I. Alkaline Phosphatase Isoenzyme in Several Gastric Lesions

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Enzymological properties of tissue alkaline phosphatase (ALP) were examined in carcinoma, intestinal metaplasia, adenomatous polyp, atypical epithelium and normal mucosa of the stomach. ALP was extracted from biopsy and surgical materials with n-butanol by Morton's method.ALP isoenzymes were examined by polyacrylamide gel disc electrophoresis and heatstability at 65°C for 15min.Heatstable ALP was seen in the tumor tissues from 6 out of 20 gastric cancers (30%) and 1 out of 28 intestinal metaplasia, while not found in the tissue from adenomatous polyp, atypical epitherium and normal gastric mucosa. There were no relationships between the incidence of heatstable ALP and differentiation of gastric carcinoma. Heatstable ALP was in partial intestinal metaplasia tissue and histological findings of which showed low grade regenerative atypism but no malignant changes.The occurence of heatstable ALP in the tissue of intestinal metaplasia is very important, because this isoenzyme has never been seen in benign tissue. Therefore, the possibility exists in the intestinal metaplasia to be of premalignant lesion, although our only experience do not make a conclusion.
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