慢性肝疾患における血清シアル酸および血清シアリルトランスフェラ-ゼ測定の意義

概要

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We mesured the levels of serum sialic acid and sialyltransferase activities in the cases of chronic liver diseases.<BR>The levels of serum sialic acid was 7.2±0.8 μg/mg protein (normal subjects), 7.8±1.0 (chronic hepatitis), 7, 2±0.8 (liver cirrhosis) and 9.1±2.8 (hepatocellur carcinoma (HCC)). Its level in decompensated cirrhosis was lower than in compensated cirrhosis and in HCC of better condition Was significantly elevated.<BR>The elevation of serum sialic acid could be one of the markers suggesting existence of HCC in the course of chronic liver disease.<BR>Serum sialyltransferase activities was parallel to the levels of serum sialic acid among the cases of chronic liver diseases.<BR>Therefore, in conclusion, the elevation of those would reflect the abnormal carbohydrate metabolism in CanCer tissue.
社団法人日本肝臓学会の論文