Effects of serum from patients with fulminant hepatic failure on bile flow.

概要

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Substances which inhibit the Na+, K +-ATPase activity in rat brain cell membrane have been found out among toxins in the circulation of patient with fulminant hepatic failure (FHF). In this examination, the effect of middle molecular serum substances from FHF patients on bile secretion was evaluated using rat. Serum ultrafiltrates and elution peaks chromatographed on Sephadex G-25 from ultrafiltrate of FHF patients were infused into rats portal vein. As a result, bile acid output in bile was reduced significantly as compared to normal control after administration of serum substances. More recently, it is strongly suggested that bile acid uptake into the hepatocyte is a coupled transport with sodium maintained by the Na+, K+-ATPase. Thus, the results in this study seem to support a hypothesis that Na+, K+-ATPase play an important role in coupling transport of bile acid and resulting in the so-called bile acid-dependent bile flow.
社団法人日本肝臓学会の論文