A case of an autonomously functioning thyroid nodule associated with low triiodothyronine concentrations.
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概要
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A 66-year-old woman with an autonomously functioning thyroid nodule (AFTN) showed low serum levels of triiodothyronine (T<SUB>3</SUB>) and no response of thyroid stimulating hormone (TSH) to thyrotropin releasing hormone (TRH). After administration of methimazole, TSH level increased from 0.1 to 19μ/U/ml. After surgical removal of the thyroid nodule, both TSH and T<SUB>3</SUB> levels increased to normal and the response of TSH to TRH stimulation became normal. These findings suggest that the AFTN may be associated with low T<SUB>3</SUB> concentrations and that certain substances released by the AFTN may be responsible for the inhibition of pituitary TSH response to TRH stimulation.
著者
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Mori Masatomo
First Department Of Internal Medicine Gunma University School Of Medicine
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Nagai Takashi
Department Of Animal Breeding And Reproduction National Institute Of Livestock And Grassland Science
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UEHARA Yutaka
First Department of Internal Medicine Gunma University School of Medicine
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Mita Yoshinori
Department of Internal Medicine, Public Tomioka General Hospital
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Sakamoto Suguru
Department of Internal Medicine, Public Tomioka General Hospital
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