Rapid Effect of nCPAP Therapy on Circulating Plasma Leptin in OSAS Patients
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概要
- 論文の詳細を見る
Obstructive sleep apnea syndrome (OSAS) is a problem of obese patients. Leptin prevents fat deposition in adipose tissue and insulin reduces plasma glucose, but levels of these hormones are sometimes high in obese patients with OSAS. Thus, leptin and insulin do not function properly in OSAS, and increase resistance to leptin and insulin may cause paradoxical state, that is, leptin and insulin resistance. The present study investigates the rapid effect of nasal continuous positive airway pressure (nCPAP) ventilation on serum leptin and insulin levels in OSAS. Levels of plasma leptin and insulin at four sampling points a day decreased in OSAS patients (*p<0.05, n=10) by nCPAP. Nocturnal mean-nadir arterial oxygen desaturation (nmSaO2) correlated with plasma leptin levels in OSAS patients (*p<0.05, n=10). Nasal CPAP did not affect circulating soluble leptin receptor levels in OSAS patients. These findings indicate that leptin and insulin are related to nocturnal hypoxia in OSAS patients, and that nCPAP have a possibility of improving leptin and insulin resistance.
- 北関東医学会の論文
- 2005-02-01
著者
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Mori Masatomo
Department Of Medicine And Molecular Science Gunma University Graduate School Of Medicine
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SHIMIZU Hiroyuki
Department of Neurosurgery, Tokyo Metropolitan Neurological Hospital
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Mita Yoshinori
Department Of Medicine And Molecular Science Gunma University Graduate School Of Medicine
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Kawata Tadayoshi
Department Of Medicine And Molecular Science Gunma University Graduate School Of Medicine
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Koga Yasuhiko
Department Of Medicine And Molecular Science Gunma University Graduate School Of Medicine
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Mori M
Department Of Internal Medicine And Molecular Science Graduate School Of Medicine Gunma University
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SHIMIZU Yasuo
Department of Second Internal Medicine, Nagoya University School of Medicine
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Shimizu Hiroyuki
Department Of Neurosurgery Faculty Of Medicine University Of Tokyo
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TSUCHIYA Takafumi
Departments of Biochemistry and Molecular Biology, Human Genetics and Medicine, The University of Ch
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Iizuka Kunihiko
Department of Internal Medicine, Public Tomioka General Hospital
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Dobashi Kunio
Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine
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Horie Takeo
Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine
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Yoshii Akihiro
Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine
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Utsugi Mitsuyoshi
Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine
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Endou Katsuaki
Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine
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Shimomura Kenjyu
Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine
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Iizuka Kimihiko
Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine
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Mori Masatomo
Department Of Internal Medicine And Molecular Science Graduate School Of Medicine Gunma University
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Mori Masatomo
The First Department Of Internal Medicine Gunma University
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Makuuchi Masatoshi
The First Department Of Internal Medicine Gunma University School Of Medicine
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Miwa Yoshihiro
The Department Of Internal Medicine Numata National Hospital
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Horie Takeo
Department Of Medicine And Molecular Science Gunma University Graduate School Of Medicine
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Horie Takeo
Department Of Life Science Graduate School Of Life Science University Of Hyogo
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Dobashi Kunio
Department Of Medicine And Molecular Science Gunma University Graduate School Of Medicine
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Shimizu Yasuo
Department Of Medicine And Molecular Science Gunma University Graduate School Of Medicine
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Yoshii Akihiro
Department Of Medicine And Molecular Science Gunma University Graduate School Of Medicine
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Endou Katsuaki
Department Of Medicine And Molecular Science Gunma University Graduate School Of Medicine
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Tsuchiya Takafumi
Department Of Medicine And Molecular Science Gunma University Graduate School Of Medicine
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Iizuka Kimihiko
Department Of Medicine And Molecular Science Gunma University Graduate School Of Medicine
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Utsugi Mitsuyoshi
Department Of Medicine And Molecular Science Gunma University Graduate School Of Medicine
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Shimomura Kenjyu
Department Of Medicine And Molecular Science Gunma University Graduate School Of Medicine
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Shimoyama Yasuyuki
Department Of Medicine And Molecular Science Gunma University Graduate School Of Medicine
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Shimizu Yasuo
Department Of Endoscopy And Endoscopic Surgery Gunma University Hospital
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Iizuka Kunihiko
The First Department Of Internal Medicine
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Mori Masatomo
The First Department Of Internal Medicine
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Shimizu Yasuo
Department 4 Technology Research Division 2 Honda R&d Co. Ltd. Automobile R&d Center
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Shimizu Hiroyuki
Department Of Epidemiology And Preventive Medicine Gifu University School Of Medicine
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Dobashi Kunio
The First Department Of Internal Medicine
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Shimizu Hiroyuki
Department Of Medicine And Molecular Science Gunma University Graduate School Of Medicine
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Makuuchi Masatoshi
The Liver Cancer Study Group Of Japan Department Of Gastroenterology And Hepatology Kinki University
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Dobashi Kunio
The 1st Department Of Internal Medicine Gunma University School Of Medicine Faculty Of Medicine
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Shimizu Hiroyuki
Department Of Chemistry Osaka University College Of Science
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Shimizu Hiroyuki
Department Of Biochemistry And Molecular Biology Center For Advanced Medical Technology Nippon Medic
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Endou Katsuaki
Department of Internal Medicine, Kiryu Kosei General Hospital
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Mita Yoshinori
Department of Internal Medicine, Public Tomioka General Hospital
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Tsuchiya Takafumi
Department of Internal Medicine, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Japan
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