Levofloxacin 300 mg Once-daily Versus Levofloxacin 100 mg Three-times-daily in the Treatment of Respiratory Tract Infections in Elderly Patients
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概要
- 論文の詳細を見る
Background & Aims : Levofloxacin (LVFX) is a newly synthesized quinolone antibiotic, and although LVFX 500 mg once-daily has been reported to have good efficacy against with respiratory tract infections in the US and other countries, once-daily the regimen seldom been used in Japan. Methods : This randomized, parallel-group, open, multicenter clinical study was designed to compare a 7-day course of LVFX 300 mg once-daily with LVFX 100 mg three-times-daily in elderly patients with respiratory tract infections. Between February 2002 and March 2003, a total of 63 patients with significant respiratory tract infections were enrolled in this study. Results : Data were available for 49 patients. The clinical cure rate was 76.0% (19/25) in the LVFX 300 mg once-daily group and 83.3% (20/24) in the LVFX 100 mg three-times-daily group. The overall clinical cure rates and overall incidences of adverse reactions were similar in both groups. There was also no significant difference in compliance between the groups. Conclusions: LVFX 300 mg once-daily is as effective and safe as LVFX 100 mg three-times-daily in elderly patients with respiratory tract infections. (Kitakanto Med J 2003 ; 53 : 251〜255) ,
- 北関東医学会の論文
- 2003-08-01
著者
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Mita Yoshinori
Department Of Medicine And Molecular Science Gunma University Graduate School Of Medicine
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Mori M
Department Of Internal Medicine And Molecular Science Graduate School Of Medicine Gunma University
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ONO AKIHIRO
Department of Internal Medicine, Saga Medical School
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SHIMIZU Yasuo
Department of Second Internal Medicine, Nagoya University School of Medicine
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Akiyama Masato
Department Of Medicine And Molecular Science (first Department Of Internal Medicine) Gunma Universit
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Dobashi Kunio
Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine
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Nakazawa Tsugio
Department of Medicine and Molecular Science (First Department of Internal Medicine), Gunma Universi
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Mori Masatomo
University School of Health Sciences
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Mori Masatomo
The First Department Of Internal Medicine Gunma University
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Makuuchi Masatoshi
The First Department Of Internal Medicine Gunma University School Of Medicine
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Miwa Yoshihiro
The Department Of Internal Medicine Numata National Hospital
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Ono Akihiro
Department Of Medicine And Molecular Science (first Department Of Internal Medicine) Gunma Universit
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Ono Akihiro
Department Of Internal Medicine Saga Medical School
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Dobashi Kunio
Department Of Medicine And Molecular Science Gunma University Graduate School Of Medicine
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Shimizu Yasuo
Department Of Medicine And Molecular Science Gunma University Graduate School Of Medicine
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Shimoyama Yasuyuki
Department Of Medicine And Molecular Science Gunma University Graduate School Of Medicine
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Shimizu Yasuo
Department Of Endoscopy And Endoscopic Surgery Gunma University Hospital
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Mori Masatomo
The First Department Of Internal Medicine
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Shimizu Yasuo
Department 4 Technology Research Division 2 Honda R&d Co. Ltd. Automobile R&d Center
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Dobashi Kunio
The First Department Of Internal Medicine
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Dobashi Kunio
The 1st Department Of Internal Medicine Gunma University School Of Medicine Faculty Of Medicine
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Akiyama Masato
Department of Internal Medicine, Public Tomioka General Hospital
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Ono Akihiro
Department of Dentistry for the Disabled, Nihon University School of Dentistry at Matsudo
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Mita Yoshinori
Department of Internal Medicine, Public Tomioka General Hospital
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