New Frontiers in Gut Nutrient Sensor Research : Monosodium L-Glutamate Added to a High-Energy, High-Protein Liquid Diet Promotes Gastric Emptying : a Possible Therapy for Patients With Functional Dyspepsia
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概要
- 論文の詳細を見る
Functional dyspepsia is a clinical syndrome that features abdominal symptoms centered in the upper abdomen without an organic basis. Three possible mechanisms of gastric dysfunction could be related to functional dyspepsia: 1) delayed gastric emptying, 2) impaired gastric accommodation to food intake, and 3) hypersensitivity to gastric distention. Delayed gastric emptying has been suggested to lead to prolonged antral distension that causes dyspeptic symptoms. Delayed gastric emptying is therefore a focal point of debate about anorexia caused by dyspepsia, and prokinetic agents are often administered in Japan for its treatment. Recently, we found that addition of monosodium L-glutamate (MSG) to a high-energy liquid diet rich in casein promoted gastric emptying in healthy men. Therefore, another potential method to improve delayed gastric emptying could be enhancement of chemosensors that activate the autonomic nervous system innervating the gastrointestinal tract. In conclusion, enrichment with glutamate promoted gastric emptying after intake of a high-protein meal, suggesting that free glutamate is important for protein digestion and that MSG may be helpful for management of delayed gastric emptying in patients with functional dyspepsia.
- 社団法人 日本薬理学会の論文
- 2010-01-20
著者
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Mori Masatomo
Department Of Medicine And Molecular Science Gunma University Graduate School Of Medicine
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Mori Masatomo
楠病院 胃腸科
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MAEDA Masaki
Department of Engineering Physics, Electronics and Mechanics, Graduate School of Engineering, Nagoya
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Mori M
Department Of Internal Medicine And Molecular Science Graduate School Of Medicine Gunma University
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ZAI Hiroaki
Department of Medicine, Tokai University School of Medicine
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Mori Masatomo
Department Of Internal Medicine And Molecular Science Graduate School Of Medicine Gunma University
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Mori Masatomo
The First Department Of Internal Medicine Gunma University
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Makuuchi Masatoshi
The First Department Of Internal Medicine Gunma University School Of Medicine
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Kusano Motoyasu
Dep. Of Medicine And Molecular Sci. Gunma Univ. Graduate School Of Medicine
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Kusano Motoyasu
Department Of Endoscopy And Endoscopic Surgery Gunma University Hospital
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Maeda Masaki
Department Of Applied Physics Faculty Of Engineering Nagoya University
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Zai Hiroaki
Department Of Medicine Tokai University School Of Medicine
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Shimizu Yasuo
Department Of Medicine And Molecular Science Gunma University Graduate School Of Medicine
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Kawamura Osamu
Department Of Medicine And Molecular Science Gunma University Graduate School Of Medicine
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SHIMOYAMA YASUYUKI
Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine
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Shimoyama Yasuyuki
Department Of Medicine And Molecular Science Gunma University Graduate School Of Medicine
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Maeda Masaki
Department Of Medicine And Molecular Science Gunma University Graduate School Of Medicine
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Hosaka Hiroko
Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan
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Nagoshi Atsuto
Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan
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Kawamura O
Department Of Medicine And Molecular Science Gunma University Graduate School Of Medicine
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Kawamura Osamu
Department Of Animal And Grassland Science Faculty Of Agriculture University Of Miyazaki
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Mori Masatomo
The First Department Of Internal Medicine Gunma University School Of Medicine
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Mori Masatomo
Department Of Medicine And Molecular Science (first Department Of Internal Medicine) Gunma Universit
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Zai Hiroaki
Department Of Medicine And Molecular Science Gunma University Graduate School Of Medicine
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Kusano Miyuki
Department Of Endoscopy And Endoscopic Surgery Gunma University Hospital
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Mori Masatomo
The First Department Of Internal Medicine
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Nagoshi Atsuto
Department Of Medicine And Molecular Science Gunma University Graduate School Of Medicine
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Mori Masatomo
The 1st Department Of Internal Medicine Gunma University School Of Medicine Faculty Of Medicine
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Hosaka Hiroko
Department Of Medicine And Molecular Science Gunma University Graduate School Of Medicine
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Makuuchi Masatoshi
The Liver Cancer Study Group Of Japan Department Of Gastroenterology And Hepatology Kinki University
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Shimoyama Yasuyuki
Department Of Endoscopy And Endoscopic Surgery Gunma University Hospital
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