Surface Expression of Toll-Like Receptor 1 is Modulated by Interferon-γ and IL-4 in Human Monocytes and B Cells
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概要
- 論文の詳細を見る
Background & Aims : Human Toll-like receptor 1 (TLR1) is a receptor which mediatied immune response to microbial lipoproteins, associates with TLR2 and recognizes the nativemycobacterial lipoprotein along with TLR2. Methods : We examined the regulation ofTLR1 surface expression in human peripheral blood monocytes and B cells by interferon-γ (IFN-γ) and interleukin-4 (IL-4). Results : IFN-γ up-regulated TLR1 surface expression on human peripheral blood monocytes and B cells. By contrast, IL-4 down-regulated TLR1 surface expression on human peripheral blood monocytes, but up-regulated TLR1 surface expression on human peripheral B cells. Conclusions : These results indicate that Th1 cytokine IFN-γ enhances receptors involved in the response to native mycobacterial lipoprotein and that activation of cellular immunity may enhance defense against mycobacterium through both monocytes and B cells, whereas Th2 cytokine IL-4 modulates the receptor response to native mycobacterial lipoprotein and that activation of humoral immunity may enhance defense against mycobacterium through B cells, but not monocytes. (Kitakanto Med J 2003 ; 53 : 191〜194)
- 北関東医学会の論文
- 2003-05-01
著者
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Mita Yoshinori
Department Of Medicine And Molecular Science Gunma University Graduate School Of Medicine
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MORI MASATOMO
First Department of Internal Medicine, Gunma University School of Medicine
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Mori M
Department Of Internal Medicine And Molecular Science Graduate School Of Medicine Gunma University
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Mori Masatomo
First Department Of Internal Medicine Gunma University School Of Medicine
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Dobashi Kunio
Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine
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Nakazawa Tsugio
Gunma University School of Health Sciences
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Mita Yoshinori
First Department of Internal Medicine, Gunma University School of Medicine
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Dobashi Kunio
First Department of Internal Medicine, Gunma University School of Medicine
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Shimizu Yasuo
First Department of Internal Medicine, Gunma University School of Medicine
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Mori Masatomo
The First Department Of Internal Medicine Gunma University
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Makuuchi Masatoshi
The First Department Of Internal Medicine Gunma University School Of Medicine
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Miwa Yoshihiro
The Department Of Internal Medicine Numata National Hospital
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Dobashi Kunio
Department Of Medicine And Molecular Science Gunma University Graduate School Of Medicine
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Shimizu Yasuo
Department Of Medicine And Molecular Science Gunma University Graduate School Of Medicine
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Shimoyama Yasuyuki
Department Of Medicine And Molecular Science Gunma University Graduate School Of Medicine
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Mori Masatomo
The First Department Of Internal Medicine
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Dobashi Kunio
The First Department Of Internal Medicine
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Dobashi Kunio
The 1st Department Of Internal Medicine Gunma University School Of Medicine Faculty Of Medicine
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Nakazawa Tsugio
Gunma University Heavy Ion Medical Center
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