CCR4-Positive T Cells in Patients with Asthma are Modulated by Suplatast Tosilate (IPD)

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概要

• 論文の詳細を見る

• Background & Aims : CXC chemokine receptor 3 (CXCR3) appears to serve as a useful marker for the identification of circulating type 1 T helper cells (Th1), whereas CC chemokine receptor 4 (CCR4) is a useful marker for circulating Th2 cells. Suplatast tosilate (IPD) is a Th2 cytokine inhibitor that decreases IgE antibody levels through specific inhibition of interleukin-4 (IL-4) and IL-5 production by T cells. We examined the effects of IPD on CXCR3- or CCR4-positive cells among CD4 and CD45RO double-positive T cells (CD4-positive memory T cells) in patients with asthma. Methods : We analyzed the T cell subsets of 10 patients with stable mild asthma before and after 4 weeks of treatment with IPD (300mg/day) in a prospective single-arm study. Results : The number of CXCR3-positive and CCR4-positive memory T cells was measured by flow cytometry. There was no significant increase of CXCR3-positive T cells in the asthma patients, but the patients showed a decrease of CCR4-positive T cells and an increase in the ratio of CXCR3-positive to CCR4-positive T cells. Conclusions : These findings indicate that IPD therapy altered the balance between CXCR3- and CCR4-positive cells in patients with asthma. (Kitakanto Med J 2003 : 53 : 185〜189)

• 北関東医学会の論文
• 2003-05-01

著者

• Mita Yoshinori

  Department Of Medicine And Molecular Science Gunma University Graduate School Of Medicine

• MORI MASATOMO

  First Department of Internal Medicine, Gunma University School of Medicine

• Mori M

  Department Of Internal Medicine And Molecular Science Graduate School Of Medicine Gunma University

• Mori Masatomo

  First Department Of Internal Medicine Gunma University School Of Medicine

• Dobashi Kunio

  Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine

• Nakazawa Tsugio

  Gunma University School of Health Sciences

• Mita Yoshinori

  First Department of Internal Medicine, Gunma University School of Medicine

• Dobashi Kunio

  First Department of Internal Medicine, Gunma University School of Medicine

• Shimizu Yasuo

  First Department of Internal Medicine, Gunma University School of Medicine

• Mori Masatomo

  The First Department Of Internal Medicine Gunma University

• Makuuchi Masatoshi

  The First Department Of Internal Medicine Gunma University School Of Medicine

• Miwa Yoshihiro

  The Department Of Internal Medicine Numata National Hospital

• Dobashi Kunio

  Department Of Medicine And Molecular Science Gunma University Graduate School Of Medicine

• Shimizu Yasuo

  Department Of Medicine And Molecular Science Gunma University Graduate School Of Medicine

• Shimoyama Yasuyuki

  Department Of Medicine And Molecular Science Gunma University Graduate School Of Medicine

• Mori Masatomo

  The First Department Of Internal Medicine

• Dobashi Kunio

  The First Department Of Internal Medicine

• Dobashi Kunio

  The 1st Department Of Internal Medicine Gunma University School Of Medicine Faculty Of Medicine

• Nakazawa Tsugio

  Gunma University Heavy Ion Medical Center

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