Metronidazole Plus Ciprofloxacin Therapy for Active Crohn's Disease
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概要
- 論文の詳細を見る
Objective The aim of this study was to investigate the efficacy of metronidazole plus ciprofloxacin for the treatment of Japanese patients with active Crohns disease. Methods and Patients Seven patients (counting one patient twice with 2 enrollments at a 5-month interval) with a flare-up of Crohns disease were enrolled. While continuing the baseline treatment under which the patients relapsed, they received metronidazole 250 mg twice (4 patients) or three times (3 patients) daily plus ciprofloxacin 200 mg three times daily for 4 weeks. The efficacy was evaluated by the changes in the assessment score of IOIBD, the International Organization for the Study of Inflammatory Bowel Disease, and the inflammation markers: C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and white blood cell count.Results Metronidazole plus ciprofloxacin decreased the CRP in seven patients and the IOIBD score in six patients. Significant differences were detected in these parameters at weeks 2 and 4 compared with baseline. Five of the patients achieved normalization of CRP and a reduction of the IOIBD score to zero or one. Although one patient complained of taste disturbance, no other adverse events occurred and all patients completed the 4 weeks of study medication. Conclusion The addition of metronidazole plus ciprofloxacin could be a useful intervention for the treatment of Japanese patients with active Crohns disease.(Internal Medicine 42: 318-321, 2003)
- 社団法人 日本内科学会の論文
- 2003-04-01
著者
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Mori Masatomo
The First Department Of Internal Medicine Gunma University
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OSHIMOTO HIROKAZU
First Department of Internal Medicine, Gunma University School of Medicine
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ISHIKAWA TAKESHI
First Department of Internal Medicine, Gunma University School of Medicine
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ISHIKAWA Takeshi
the First Department of Internal Medicine, Gunma University
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Okamura Shinichi
The First Department Of Internal Medicine Gunma University
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Makuuchi Masatoshi
The First Department Of Internal Medicine Gunma University School Of Medicine
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Oshimoto Hirokazu
The First Department Of Internal Medicine Gunma University
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Kobayashi Ryota
The First Department Of Internal Medicine Gunma University
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Mori Masatomo
Department Of Medicine And Molecular Science (first Department Of Internal Medicine) Gunma Universit
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Mori Masatomo
The First Department Of Internal Medicine
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Ishikawa Takeshi
The First Department Of Internal Medicine Gunma University
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