The opsonizing activity to Streptococcus pneumoniae type I in patients with immunodeficiencies during immunoglobulin replacement therapy

概要

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We studied the opsonizing activity to Streptococcus pneumoniae type I (Sp) in 7 patients with the immunoglobulin replacement therapy. They are one patient with symptomatic IgG2 subclass deficiency and 6 patients with common variable immunodeficiency. Using luminol dependent chemiluminescence (CL), we measured the maximum (peak) cpm of CL with polymorphonuclear leukocytes (PMN) isolated from a single normal adult and stimulated with opsonized Sp's.The results of CL correlated with the immunoglobulin level of the same serum in cases with normal states but not with infectious state of the respiratory tract and with IgG2 subclass deficiency. And also low CL correlated more closely with infectious states than the immunoglobulin levels of each patients.Our results suggest that the CL under our condition can measure more directly the antipneumococcal opsonizing antibody in vivo than the semi-quantitative assay of spesific antibody as enzyme-linked immunosolbent assay, and is a useful aid at the screening of IgG2 subclass deficiency.We suggest that the opsonizing activity to Sp is more useful than the levels of serum immunoglobulin in setting the schedule of replacement therapy, especially to prevent and cure the bacterial respiratory tract infections in the patients with hypogammaglobulinemia.
日本臨床免疫学会の論文