Potentiating effect of methysergide on norepinephrine-induced constriction of the isolated internal carotid artery of the dog.
スポンサーリンク
概要
- 論文の詳細を見る
The stainless steel cannula inserting method was used to examine the effects of methysergide on 5-hydroxytryptamine (5-HT)-and norepinephrine-induced vasoconstriction in the isolated internal carotid artery of the dog. 5-HT, at a dose of 0.3 μg, induced a marked increase in perfusion pressure, usually over 100 mm Hg. On the other hand, norepinephrine produced a relatively small increase in perfusion pressure (20-40 mm Hg) at a large dose of 10 μg. Methysergide inhibited 5-HT-induced vasconstriction. Norepinephrine-induced vasoconstriction was significantly potentiated by treatment with methysergide and blocked by phentolamine. Methysergide also enhanced the vasoconstrictor response to potassium chloride. Thus, it is suggested that the potentiating effect of methysergide on norepinephrine-induced vasoconstriction may partially be due to activation of the inward calcium channel of the internal carotid artery.
- 公益社団法人 日本薬理学会の論文
著者
-
Tsuji Tsutomu
Department Of Legal Medicine Wakayama Medical University
-
Chiba Shigetoshi
Departmen T Of Pharmacology Shinshu University School Of Medicine
-
TSUJI Tsutomu
Department of Neurosurgery, Shinshu University School of Medicine
関連論文
- Lung-heart weight ratio as a possible index of cardiopulmonary pathophysiology in drowning
- Postmortem lung weight in drownings : a comparison with acute asphyxiation and cardiac death
- Amino Acid Sequence and Characterization of a Rice Bran Ribonuclease
- Effect of Modification of the Carboxyl Groups of the Sialic Acid Binding Lectin from Bullfrog(Rana catesbeiana)Oocyte on Anti-tumor Activity
- Acetylcholine-Induced Translocation of RhoA in Freshly Isolated Single Smooth Muscle Cells of Rat Bronchi
- Periarterial Electrical Nerve Stimulation-Induced Adrenergic Vasoconstriction Inhibited by Adrenergic α_-Receptor Blockade but Not by α_-Blockade
- Different Sensitivities to α_1 Adrenoceptor Blockade on Periarterial Sympathetic Nerve-Induced Constriction by Low and High Frequencies in Canine Isolated Splenic Arteries
- Effects of Imipramine, an Uptake Inhibitor, on Double-Peaked Constrictor Responses to Periarterial Nerve Stimulation in Isolated, Per fused Canine Splenic Arteries
- Effects of Prolonged Cold Storage on Purinergic and Adrenergic Components of Sympathetic Co-transmission in Isolated Canine Splenic Arteries
- Neuroeffector Mechanisms Involved in the Regulation of Dog Splenic Arterial Tone
- Perivascular Purinergic Nerve-Induced Vasoconstrictions in Canine Isolated Splenic Arteries
- Effects of Neuropeptide Y on Double-Peaked Constrictor Responses to Periarterial Nerve Stimulation in Isolated, Perfused Canine Splenic Arteries
- Effect of Replacing the Aspartic Acid / Glutamic Acid Residues of Bullfrog Sialic Acid Binding Lectin with Asparagine / Glutamine and Arginine on the Inhibition of Cell Proliferation in Murine Leukemia P388 Cells
- Enzymatic Properties of Sialic Acid Binding Lectin from Rana catesbeiana Modified with a Water-Soluble Carbodiimide in the Presence of Various Nucleophiles
- Pulmonary immunohistochemistry and serum levels of a surfactant-associated protein A in fatal drowning
- Exclusion of Actin-Binding Protein p57/Coronin-1 from Bacteria-Containing Phagosomes in Macrophages Infected with Legionella(Microbiology)
- Gene Expression of MASH-1, MATH-1, neuroD and NSCL-2, Basic Helix-Loop-Helix Proteins, during Neural Differentiation in P19 Embryonal Carcinoma Cells
- Botulinum Neurotoxin A Blocks Cholinergic Ganglionic Neurotransmission in the Dog Heart
- A Na^+/Ca^ Exchanger Inhibitor, KB-R7943, Caused Negative Inotropic Responses and Negative Followed by Positive Chronotropic Responses in Isolated, Blood-Perfused Dog Heart Preparations
- Propofol decreases contractility of isolated blood-perfused left ventricular muscle in the dog
- Cardiac effects of propofol and its interaction with autonomic nervous system in isolated, cross-circulated canine atria
- Effects of Low Temperature on the Chronotropic and Inotropic Responses to Zatebradine, E-4031 and Verapamil in Isolated Per fused Dog Atria
- Different Chronotropic and Inotropic Effects of EMD 57033 and EMD 53998, Ca^ Sensitizers, on Isolated, Blood-Perfused Dog Heart Preparations
- Inhibition of Delayed Rectifier K^+ Current by Dofetilide and E-4031 Differentially Affects Electrical Cardiac Responses to Vagus Stimulation in Anesthetized Dogs
- Negative Chronotropic and Inotropic Effects of U-92032, a Novel T-Type Ca^ Channel Blocker, on the Isolated, Blood-Perfused Dog Atrium
- Differences in α_1-Adrenoceptor Subtype-Mediated Vasoconstriction by Tyramine and Nerve Stimulation in Canine Splenic Artery
- Laminin-511, inducer of hair growth, is down-regulated and its suppressor in hair growth, laminin-332 up-regulated in chemotherapy-induced alopecia
- Dissociation of Potentiation of Leu^ Pro^ Neuropeptide Y on Adrenergic and Purinergic Transmission in Isolated Canine Splenic Artery
- Transient Expression of a Brain/Embryonic-Type Myosin Heavy Chain Isoform (MIIB2) in Regenerating Rat Liver
- Suprachiasmal Carotid-ophthalmic Artery Aneurysm : Report of Two Cases
- Effects of Magnesium on the Isolated, Blood-Perfused Atrial and Ventricular Preparations of the Dog Heart
- MECHANISM OF POSITIVE CHRONOTROPIC AND INOTROPIC EFFECTS INDUCED BY 4-METHYLHISTAMINE
- Chronotropic and Inotropic Effects of Bradykinin on Isolated, Blood-perfused Canine Atrium
- Effects of Temperature on Inotropic Responses of Isolated Canine Atria under Spontaneous or Electrically Paced Rhythm
- A Pharmacologic Analysis of Chronotropic and Inotropic Responses to Direct Electrical Stimulation of the Isolated, Blood-perfused. Canine Atrium
- Cardiac Arrest and Reactivation by Changes of Temperature in the Isolated, Blood-perfused Canine Heart
- Absence of Acute Cardiac Effect of Triiodothyronine in Isolated, Blood-perfused Canine Atrium
- EFFECT OF NIFEDIPINE ON FREQUENCY-FORCE RELATIONSHIP IN ISOLATED DOG LEFT VENTRICULAR MUSCLE
- POTENTIATION OF TYRAMINE ACTION BY 5-HYDROXYTRYPTAMINE IN THE DOG HEART
- Effects of Cardioactive Substances on the Post-stimulation Potentiation of Contractility in the Isolated Dog Atrium
- Effects of Optical Isomers of Verapamil on SA Nodal Pacemaker Activity and Contractility of the Isolated Dog Heart
- Direct Positive Chronotropic and Inotropic Effects of Ouabain in the Isolated and Blood-Perfused Canine Atrium
- Cutaneous mixed tumors : an immunohistochemical study using two antibodies, G-81 and C8/144B
- CHRONOTROPIC RESPONSES TO LARGE DOSES OF ADENOSINE AND ATP IN DOG ISOLATED ATRIA
- DOUBLE-PEAKED POSITIVE CHRONOTROPIC RESPONSES OF ISOLATED AND CROSS-PERFUSED DOG ATRIA TO ATP
- Direct Effects of Digoxin and Deslanoside on Sinoatrial Conduction in Isolated, Blood-perfused Dog Atria
- Acute Desensitization of Adenosine by Adenosine Infusion in Isolated Dog Atria
- Dominant Anti-vagal Effect of Pentobarbital on Cardiac Responses to Intracardiac Autonomic Nerve Stimulation in the Dog
- Cardiovascular Effects of Aminophylline and Pentoxifylline on Intact Dogs and Isolated Dog Atria
- EFFECTS OF IMIPRAMINE ON FREQUENCY-FORCE RELATIONSHIP IN ISOLATED RIGHT ATRIAL MUSCLE OF THE DOG
- EFFECTS OF NICARDIPINE ON THE CROSS-PERFUSED CANINE ATRIUM
- Cardiovascular Effects of Imipramine in Intact Dogs and Isolated Dog Atria
- Analysis of Cardiac Actions of Nitroprusside in Intact Dogs and in Isolated Atria
- Chronotropic and Inotropic Effects of Captopril on the Dog Heart
- CARDIAC STIMULATING EFFECTS OF MACROCYCLIC POLYAMINES
- EFFECT OF ADENOSINE ON THE FREQUENCY-FORCE RELATIONSHIP IN THE ISOLATED DOG ATRIUM
- COMPARISON OF THE EFFECTS OF NOREPINEPHRINE AND ACETYLCHOLINE BETWEEN INTRAARTERIAL AND EXTRAVASCULAR ADMINISTRATION TO THE ISOLATED, BLOOD-PERFUSED CANINE ATRIUM
- Differences in Chronotropic and Inotropic Responses of Canine Atrial Muscle and SA Node Pacemaker Activity to Adenosine and ACh
- Acetylcholine-Induced Translocation of RhoA in Freshly Isolated Single Smooth Muscle Cells of Rat Bronchi
- EFFECTS OF CYCLIC GMP ON THE SECRETION OF PANCREATIC JUICE IN THE BLOOD-PERFUSED CANINE PANCREAS
- Existence of Functional α_- and α_- but No α_-Adrenoceptor Subtypes in Rat Common Carotid Arteries
- Effects of Temperature on Norepinephrine-Induced Sinus Acceleration and Overdrive Suppression in the Isolated Dog Atrium
- Pharmacologic Analysis of Stretch-Induced Sinus Acceleration of the Isolated Dog Atrium
- EFFECTS OF METHYLISOBUTYLXANTHINE (MIX) ON THE SECRETION OF PANCREATIC JUICE IN THE BLOOD-PERFUSED CANINE PANCREAS
- POTENTIATING EFFECTS OF DIPYRIDAMOLE ON THE SECRETION OF PANCREATIC JUICE INDUCED BY SECRETIN IN THE BLOOD-PERFUSED DOG PANCREAS
- DIFFERENT INOTROPIC RESPONSES TO ADENOSINE ON THE ATRIAL AND VENTRICULAR MUSCLE OF THE DOG HEART
- DIFFERENTIAL INOTROPIC-CH RONOTROPIC ACTION OF CARTEOLOL
- Effects of L-765,314, a Selective and Potent α_-Adrenoceptor Antagonist, on Periarterial Nerve Electrical Stimulation-Induced Double-Peaked Constrictor Responses in Isolated Dog Splenic Arteries
- CARDIOVASCULAR EFFECTS OF DOBUTAMINE, DOPAMINE AND ISOPROTERENOL ON THE WHOLE ANIMAL AND ISOLATED CROSS-PERFUSED ATRIUM IN DOGS
- EFFECT OF PROSTAGLANDINS E1 AND F2α ON HEART RATE BY DIRECT INJECTION INTO THE CANINE SINUS NODE ARTERY
- The Preferential Inhibitory Effect of Olmesartan, a New Angiotensin II Type 1 Antagonist, on Sympathetic Nerve Terminals in Isolated Canine Splenic Artery
- Enhancement of Vasoconstrictor Responses to 5-HT but no to Methoxamine by Cooling in Isolated Dog Lingual and Mesenteric Arteries
- COMPARATIVE STUDY OF THE SECRETORY RESPONSE TO DOPAMINE AND SEVEN AMINO ACID CONJUGATED DERIVATIVES ON THE BLOOD-PERFUSED CANINE PANCREAS
- EFFECT OF ACETAZOLAMIDE ON THE SECRETION OF PANCREATIC JUICE INDUCED BY DOPAMINE IN DOGS
- Effect of Apomorphine on the Canine SA Node
- Effects of Salmon Calcitonin on SA Nodal Pacemaker Activity and Contractility in Isolated, Blood-Perfused Atrial and Papillary Muscle Preparations of Dogs
- Effects of Potassium Chloride on Isolated, Blood-Perfused Canine Atrial or Ventricular Muscle Preparations
- Cardiac effects of YM-09538, a new .ALPHA.- and .BETA.-adrenoceptor blocking agent, on SA nodal pacemaker activity and contractility in isolated atria and intact dogs.
- Chronotropic and inotropic effects of 3 kinds of alpha-adrenergic blockers on the isolated dog atria.
- Absence of blocking effect of burimamide and metiamide on positive chronotropic and inotropic responses to histamine in isolated dog atrium.
- Coronary Sinus Rhythm Induced by Selective Use of Catecholamine in the in Situ Dog Heart
- Negative Chronotropic Response to Norepinephrine
- SUSTAINED ATRIAL FIBRILLATION INDUCED BY CARBACHOL, METHACHOLINE AND BETHANECHOL
- DIFFERENCES IN CHRONOTROPIC AND DROMOTROPIC RESPONSES OF THE SA AND AV NODES TO ADENOSINE AND ACETYLCHOLINE
- Effect of verapamil on frequency-force relationship in isolated dog left ventricular muscle.
- Sympathetic Nerve Stimulation Activates Both .BETA.1- and .BETA.2- Adrenoceptors of SA and AV Nodes in Anesthetized Dog Hearts.
- A Negative Inotropic Effect of Omega-Conotoxin GVIA in Isolated, Blood-Perfused Dog Right Atria.
- Pharmacological analysis of positive chrono- and inotropic responses to denopamine (TA-064) in dog cross-circulated atrial and ventricular preparations.
- Cardiovascular effects of 2-amino-N-(2,6-dimethylphenyl)-N-(3-(3-pyridyl)propyl)propionamide dihydrochloride(Ro 22-9194) in the isolated, cross-perfused atrium of the dog.
- Pharmacological analysis of cardiac effects of a central cholinergic agent, WEB 1881-FU, in isolated canine heart preparations.
- Cardiovascular responses to a newly developed phosphodiesterase inhibitor, DN-9693 (7-pyperidinyl-1,2,3,5-tetrahydroimidazo (2,1-b)-quinazolin-2-oneHCl) in dog cross-circulated atrial and ventricular preparations.
- Direct chronotropic and inotropic effects of mildronate using cross-circulated dog atrial and ventricular preparations.
- Cardiovascular effects of methylflavonolamine hydrochloride(SIPI-549) in cross-circulated canine atrial and ventricular preparations.
- Effects of Phentolamine on the SA Node of the Dog Heart In Situ
- BLOCKING EFFECT OF DESMETHYLIMIPRAMINE ON DOPAMINE-INDUCED SINUS ACCELERATION
- PHARMACOLOGIC ANALYSIS OF NICOTINE AND DIMETHYLPHENYLPIPERAZINIUM ON PACEMAKER ACTIVITY OF THE SA NODE IN THE DOG
- Effect of Bethanechol, Methacholine and Carbachol on AV Conduction of the Dog Heart
- Absence of Blocking Effect of Quinidine on Responses to Norepinephrine in the Isolated Dog Atrium
- Effects of Verapamil on the Blood-Perfused, Isolated Atrium Preparation of the Dog Heart
- Potentiating effect of methysergide on norepinephrine-induced constriction of the isolated internal carotid artery of the dog.