Effects of cimetidine on prostanoid production in the gastric corpus specimens from rats.
スポンサーリンク
概要
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In order to examine the effect of cimetidine on the production of prostanoids in the stomach mucosa, the amounts of prostaglandin (PG) E<SUB>2</SUB>, F<SUB>1α</SUB> and thromboxane (TX) B<SUB>2</SUB> were determined after the specimens from the rat stomach corpus were incubated in the presence of cimetidine. Cimetidine significantly stimulated the production of PGE<SUB>2</SUB> in the specimens at a concentration of 10 μM, but did not significantly affect the production of PGF<SUB>1α</SUB> and TXB<SUB>2</SUB> at concentrations of 1 to 100 μM.
- 公益社団法人 日本薬理学会の論文
著者
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Kubota Kazuhiko
Department Of Pharmacology Faculty Of Pharmaceutical Science Science University Of Tokyo
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SUGAYA Kiminobu
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Science University of Tokyo
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HOTTA Kyoko
Department of Biochemistry and Internal Medicine, Kitasato University School of Medicine
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