Reversal of antinociceptive effect of cholecystokinin by benzodiazepines and a benzodiazepine antagonist, Ro 15-1788.
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概要
- 論文の詳細を見る
Intraperitoneally administered benzodiazepines, chlordiazepoxide (2-5 mg/kg), diazepam (1 mg/kg), flurazepam (1 mg/kg) and a benzodiazepine antagonist, Ro 15-1788 (0.5 mg/kg), reversed the antinociceptive effect in mice which was induced by intracisternal administration of 1 μg of sulfated cholecystokinin octapeptide. The antinociceptive effect of cholecystokinin was reversed by naloxone, suggesting that the antinociceptive action involves endogenous opioid peptides in its production. On the other hand, morphine-induced analgesia was not reversed by diazepam and Ro 15-1788. These facts rule out opioid receptors as the site of the antagonism between the benzodiazepines or Ro 15-1788 and cholecystokinin on the antinociceptive effect. Benzodiazepines and Bo 15-1788 seem to inhibit the release of opioid peptides induced by cholecystokinin.
- 公益社団法人 日本薬理学会の論文
著者
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Matsuoka Yutaka
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Kubota Kazuhiko
Department Of Pharmacology Faculty Of Pharmaceutical Science Science University Of Tokyo
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TERAWAKI Yasufumi
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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MATSUOKA Yutaka
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Science University of Tokyo
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SUGAYA Kiminobu
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Science University of Tokyo
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MATSUDA Ikuko
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Science University of Tokyo
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