Inhibition of cholecystokinin response in the gallbladder by dibenamine and its protection by benzodiazepines.
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概要
- 論文の詳細を見る
The contractile response of the guinea-pig gallbladder to cholecystokinin (CCK) and acetylcholine (ACh) was irreversibly inhibited by 5×10<SUP>-5</SUP> M dibenamine, and the dibenamine-induced inhibition in the CCK response was prevented by 10<SUP>-4</SUP> M chlordiazepoxide (CDP) and diazepam (DZP), but not by 10<SUP>-2</SUP> M proglumide or 10<SUP>-6</SUP> M atropine. The dibenamine-induced inhibition in the ACh response was prevented by 10<SUP>-6</SUP> M atropine, but not by 10<SUP>-4</SUP> M CDP. These findings suggest that the binding of CCK to the CCK receptor can be inhibited by benzodiazepines.
- 公益社団法人 日本薬理学会の論文
著者
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Kubota Kazuhiko
Department Of Pharmacology Faculty Of Pharmaceutical Science Science University Of Tokyo
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Itonaga Masahiro
Department Of Gastroenterology Kyoto Second Red Cross Hospital
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Sunagane Nobuyoshi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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SUGAYA Kiminobu
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Science University of Tokyo
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FUJII Fumio
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Science University of Tokyo
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