Possible mechanisms of spasmolytic action of bile salts on the isolated guinea-pig gallbladder.
スポンサーリンク
概要
- 論文の詳細を見る
Sunagane N., T. Kobori, T. Uruno and K. Kubota. <I>Possible mechanisms of spasmolytic action of bile salts on the isolated guinea-pig gallbladder</I>. The spasmolytic action of bile salts on gallbladder smooth muscle could explain the alleged relief of biliary colic seen during bile acid therapy. The mechanisms of spasmolytic action of bile salts, ursodeoxycholate and deoxycholate were studied in the isolated gallbladder of guinea-pigs. The bile salts accelerated the <SUP>45</SUP>Ca-efflux from the gallbladder with synchronous relaxation and inhibited the cellular <SUP>45</SUP>Ca-uptake by the depolarized muscle preparation. Further, they sensitively inhibited CaCl<SUB>2</SUB>-induced contraction of the depolarized muscle. The tissue cyclic AMP content of the gallbladder was significantly elevated by the bile salts. Dibutyryl cyclic AMP mimicked the effects of bile salts on the Ca-efflux and the muscle relaxation, but showed no effect on the cellular Ca-uptake. From these results, it is suggested that the bile salts produce the relaxant action through accelerating Ca-efflux, which is probably coupled with the elevation of the cellular cyclic AMP level, and through suppressing the Ca-influx across the cell membrane.
- 日本平滑筋学会の論文
著者
-
Uruno Tsutomu
Department Of Pharmacology Faculty Of Pharmaceutical Science Science University Of Tokyo
-
Kubota Kazuhiko
Department Of Pharmacology Faculty Of Pharmaceutical Science Science University Of Tokyo
-
Kobori Tatsumi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Science University Of Tokyo
-
Sunagane Nobuyoshi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Science University Of Tokyo
関連論文
- COMPARISON OF EFFECTS OF EXTERNAL Ca^ ON ANTIOXYTOCIN ACTIONS OF ANTISPASMODICS IN OVARIECTOMIZED AND ESTRADIOL-TREATED RAT UTERI
- STUDIES ON MECHANISMS OF DIARRHEA INDUCED BY FUSARENON-X, A TRICHOTHECENE MYCOTOXIN FROM FUSARIUM SPECIES : CHARACTERISTICS OF INCREASED INTESTINAL ABSORPTION RATE INDUCED BY FUSARENON-X
- MECHANISM OF RELAXANT ACTION OF PAPAVERINE. II. DIFFERENCES BETWEEN MODES OF RELAXANT EFFECTS OF PAPAVERINE AND AMYTAL IN GUINEA-PIG TAENIA COLI
- DETERMINATION OF CALCIUM IONS EFFLUXED FROM SMOOTH MUSCLE INTO Ca^-FREE PHYSIOLOGICAL SOLUTION BY MEANS OF Ca^-SELECTIVE ELECTRODE
- ACTIONS OF PAPAVERINE, ASPAMINOL AND BILE SALTS AND INTRACELLULAR CYCLIC AMP LEVEL
- COMPARISON OF ACTIONS OF PAPAVERINE, ASPAMINOL AND ISOPRENALINE ON ISOLATED RAT UTERUS
- ANTI-OXYTOCIN ACTIONS OF PAPAVERINE, ASPAMINOL AND ISOPRENALINE ON THE RAT UTERUS AND INTRACELLULAR CYCLIC ADENOSINE 3, 5-MONOPHOSPHATE LEVEL
- MECHANISM OF RELAXANT ACTION OF PAPAVERINE. III. COMPARISON OF SODIUM ION DEPENDENCIES ON THE RELAXANT EFFECTS OF PAPAVERINE, ASPAMINOL AND BENACTYZINE IN GUINEA-PIG TAENIA COLI
- Characteristics of contractile response and calcium mobilization in the stomach fundus of spontaneously hypertensive rats
- MECHANISMS OF SPASMOLYTIC ACTION OF BILE SALTS IN DEPOLARIZED GUINEA-PIG TAENIA COLI
- INTERACTION BETWEEN CHOLECYSTOKININ AND BENZODIAZEPINE RECEPTOR LIGANDS
- MECHANISM OF RELAXANT ACTION OF PAPAVERINE. EFFECT ON CAFFEINE-INDUCED CONTRACTION OF GUINEA PIG TAENIA COLI
- REVERSAL OF ANTINOCICEPTIVE EFFECT OF CAERULEIN BY BENZODIAZEPINE
- EFFECTS OF PAPAVERINE, BENACTYZINE AND D600 ON Ca2+ EFFLUX, DETERMINED BY MEANS OF A Ca2+-SELECTIVE ELECTRODE, FROM GUINEA PIG TAENIA COLI INTO A Ca2+-FREE PHYSIOLOGICAL SOLUTION
- EFFECTS OF HIGH POTASSIUM DEPOLARIZATION, CARBACHOL AND OXYTOCIN ON THE LANTHANUM-RESISTANT 45Ca FRACTION IN RAT MYOMETRIUM
- Possible Involvement of the CCK Receptor in the Benzodiazepine Antagonism to CCK in the Mouse Brain
- Characteristics of Antinociception Induced by Noncatecholic Phenylethylamine Derivatives: The Involvement of Alpha-2-Adrenoceptors.
- Reversal of antinociceptive effect of cholecystokinin by benzodiazepines and a benzodiazepine antagonist, Ro 15-1788.
- Characteristics of analgesia induced by noncatecholic phenylethylamine derivatives: Possible involvement of endogenous opioid peptides and serotonin in phenylethylamine analog-induced analgesia.
- 2S,3R 3-Amino-2-hydroxy-4-phenylbutanoic acid derivatives, enkephalinase inhibitors, augment met5-enkephalin-induced antinociception.
- Caerulein antagonism by benzodiazepines in the food intake in mice.
- Possible mechanisms of spasmolytic action of bile salts on the isolated guinea-pig gallbladder.
- Inhibition of hypothermic effect of cholecystokinin by benzodiazepines and a benzodiazepine antagonist, Ro 15-1788, in mice.
- Inhibition of cholecystokinin response in the gallbladder by dibenamine and its protection by benzodiazepines.
- Effects of sucrose- or Tris-substitution for Na+ on responses to D 600, papaverine and KCN in the K+-depolarized taenia coli of guinea pigs.
- Effects of cimetidine on prostanoid production in the gastric corpus specimens from rats.
- Possible Mechanisms of Action of the Antispasmodic Agent Tiropramide in the Isolated Detrusor from Rats.
- Characteristics of antinociception induced by noncatecholic phenylethylamine derivatives: The relation of endogenous norepinephrine to phenylethylamine analog-induced antinociception.
- Inhibition of .BETA.-CCM of cholecystokinin-induced release of acetylcholine from the longitudinal muscle-myenteric plexus preparation in the guinea-pig ileum.
- Mechanism of relaxant action of papaverine. IV. Roles of sodium ion and cyclic AMP.
- Mechanism of relaxant action of papaverine. VI. Sodium ion dependence of its effect on 45Ca-efflux in guinea-pig taenia coli.
- Mechanisms of inhibitory action of phenylephrine in guinea-pig taenia coli.
- Cholecystokinin antagonism by .BETA.-carboline esters in the central nervous system in mice.
- 2-Deoxy-d-(14C)-glucose study of the interaction of caerulein and apomorphine.
- .BETA.-Carbolines selectively antagonize the cholecystokinin action in isolated guinea-pig gallbladder muscle.