COMPARISON OF EFFECTS OF EXTERNAL Ca^<2+> ON ANTIOXYTOCIN ACTIONS OF ANTISPASMODICS IN OVARIECTOMIZED AND ESTRADIOL-TREATED RAT UTERI
スポンサーリンク
概要
- 論文の詳細を見る
The influence of Ca^<2+> on the antioxytocin actions of papaverine, deoxycholate and 1,1-diphenyl-3-piperidinobutanol hydrochloride (Aspaminol) was investigated in the ovariectomized and the estradiol-treated rat uteri, and Ca exchangeability and Ca content in both uteri were compared. No qualitative difference in the responses to deoxycholate and Aspaminol at normal and higher Ca^<2+> concentrations in the estradiol-treated rat uterus was seen as compared to those obtained from the ovariectomized one. The antioxytocin action of papaverine in the estrogenized uterus was antagonized by excess external Ca^<2+>, but not in the ovariectomized one. There were no significant differences either in the total Ca content or the non-displaceable Ca by La between the ovariectomized and the estrogenized rat uterine longitudinal muscle layers, while Ca exchangeability in the estrogenized specimen was much greater than that in the ovariectomized one. These results suggest that the antagonism of papaverine against excess exogenous Ca^<2+> may be related to the more increased Ca exchangeability in the estradiol-treated rat myometrium.
- 社団法人日本薬学会の論文
著者
-
Tabata Keiichi
Department Of Pharmacology Institute Of Natural Medicine Toyama Medical And Pharmaceutical Univerity
-
Tabata Keiichi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Science University Of Tokyo
-
URUNO TSUTOMU
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Science University of Tokyo
-
SUZUKI MINAKO
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Science University of Tokyo
-
SEKIGUCHI TERUYUKI
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Science University of Tokyo
-
ARAKI HAMAJI
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Science University of Tokyo
-
KUBOTA KAZUHIKO
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Science University of Tokyo
-
Araki Hamaji
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Science University Of Tokyo
-
Suzuki Minako
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Science University Of Tokyo
-
Uruno T
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Science University Of Tokyo
-
Uruno Tsutomu
Department Of Pharmacology Faculty Of Pharmaceutical Science Science University Of Tokyo
-
Uruno Tsutomu
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Science University Of Tokyo
-
Kubota Kazuhiko
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Science University Of Tokyo
-
Kubota Kazuhiko
Department Of Pharmacology Faculty Of Pharmaceutical Science Science University Of Tokyo
-
Sekiguchi Teruyuki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Science University Of Tokyo
関連論文
- COMPARISON OF EFFECTS OF EXTERNAL Ca^ ON ANTIOXYTOCIN ACTIONS OF ANTISPASMODICS IN OVARIECTOMIZED AND ESTRADIOL-TREATED RAT UTERI
- Ameliorative Effects of Paeoniflorin, a Major Constituent of Peony Root, on Adenosine A_1 Receptor-Mediated Impairment of Passive Avoidance Performance and Long-Term Potentiation in the Hippocampus
- Paeoniflorin, a Major Constituent of Peony Root, Reverses Muscarinic M_1-Receptor Antagonist-Induced Suppression of Long-Term Potentiation in the Rat Hippocampal Slice
- STUDIES ON MECHANISMS OF DIARRHEA INDUCED BY FUSARENON-X, A TRICHOTHECENE MYCOTOXIN FROM FUSARIUM SPECIES : CHARACTERISTICS OF INCREASED INTESTINAL ABSORPTION RATE INDUCED BY FUSARENON-X
- CHARACTERISTIC OF ANTINOCICEPTIVE EFFECT OF A TETRAPEPTIDE, Asn-Ala-Gly-Ala (NAGA)
- MECHANISM OF RELAXANT ACTION OF PAPAVERINE. II. DIFFERENCES BETWEEN MODES OF RELAXANT EFFECTS OF PAPAVERINE AND AMYTAL IN GUINEA-PIG TAENIA COLI
- DETERMINATION OF CALCIUM IONS EFFLUXED FROM SMOOTH MUSCLE INTO Ca^-FREE PHYSIOLOGICAL SOLUTION BY MEANS OF Ca^-SELECTIVE ELECTRODE
- ACTIONS OF PAPAVERINE, ASPAMINOL AND BILE SALTS AND INTRACELLULAR CYCLIC AMP LEVEL
- COMPARISON OF ACTIONS OF PAPAVERINE, ASPAMINOL AND ISOPRENALINE ON ISOLATED RAT UTERUS
- ANTI-OXYTOCIN ACTIONS OF PAPAVERINE, ASPAMINOL AND ISOPRENALINE ON THE RAT UTERUS AND INTRACELLULAR CYCLIC ADENOSINE 3, 5-MONOPHOSPHATE LEVEL
- MECHANISM OF RELAXANT ACTION OF PAPAVERINE. III. COMPARISON OF SODIUM ION DEPENDENCIES ON THE RELAXANT EFFECTS OF PAPAVERINE, ASPAMINOL AND BENACTYZINE IN GUINEA-PIG TAENIA COLI
- Characteristics of contractile response and calcium mobilization in the stomach fundus of spontaneously hypertensive rats
- MECHANISMS OF SPASMOLYTIC ACTION OF BILE SALTS IN DEPOLARIZED GUINEA-PIG TAENIA COLI
- INTERACTION BETWEEN CHOLECYSTOKININ AND BENZODIAZEPINE RECEPTOR LIGANDS
- MECHANISM OF RELAXANT ACTION OF PAPAVERINE. EFFECT ON CAFFEINE-INDUCED CONTRACTION OF GUINEA PIG TAENIA COLI
- REVERSAL OF ANTINOCICEPTIVE EFFECT OF CAERULEIN BY BENZODIAZEPINE
- EFFECTS OF PAPAVERINE, BENACTYZINE AND D600 ON Ca2+ EFFLUX, DETERMINED BY MEANS OF A Ca2+-SELECTIVE ELECTRODE, FROM GUINEA PIG TAENIA COLI INTO A Ca2+-FREE PHYSIOLOGICAL SOLUTION
- EFFECTS OF HIGH POTASSIUM DEPOLARIZATION, CARBACHOL AND OXYTOCIN ON THE LANTHANUM-RESISTANT 45Ca FRACTION IN RAT MYOMETRIUM
- A COMPARISON OF pD2 VALUES OF ANTISPASMODICS OBTAINED BY CUMULATIVE AND NON-CUMULATIVE TECHNIQUES IN THE RAT UTERUS
- Possible Involvement of the CCK Receptor in the Benzodiazepine Antagonism to CCK in the Mouse Brain
- Characteristics of Antinociception Induced by Noncatecholic Phenylethylamine Derivatives: The Involvement of Alpha-2-Adrenoceptors.
- Reversal of antinociceptive effect of cholecystokinin by benzodiazepines and a benzodiazepine antagonist, Ro 15-1788.
- Characteristics of analgesia induced by noncatecholic phenylethylamine derivatives: Possible involvement of endogenous opioid peptides and serotonin in phenylethylamine analog-induced analgesia.
- 2S,3R 3-Amino-2-hydroxy-4-phenylbutanoic acid derivatives, enkephalinase inhibitors, augment met5-enkephalin-induced antinociception.
- Caerulein antagonism by benzodiazepines in the food intake in mice.
- Possible mechanisms of spasmolytic action of bile salts on the isolated guinea-pig gallbladder.
- Inhibition of hypothermic effect of cholecystokinin by benzodiazepines and a benzodiazepine antagonist, Ro 15-1788, in mice.
- Inhibition of cholecystokinin response in the gallbladder by dibenamine and its protection by benzodiazepines.
- Effects of sucrose- or Tris-substitution for Na+ on responses to D 600, papaverine and KCN in the K+-depolarized taenia coli of guinea pigs.
- Effects of cimetidine on prostanoid production in the gastric corpus specimens from rats.
- Possible Mechanisms of Action of the Antispasmodic Agent Tiropramide in the Isolated Detrusor from Rats.
- Characteristics of antinociception induced by noncatecholic phenylethylamine derivatives: The relation of endogenous norepinephrine to phenylethylamine analog-induced antinociception.
- Inhibition of .BETA.-CCM of cholecystokinin-induced release of acetylcholine from the longitudinal muscle-myenteric plexus preparation in the guinea-pig ileum.
- Mechanism of relaxant action of papaverine. IV. Roles of sodium ion and cyclic AMP.
- Mechanism of relaxant action of papaverine. VI. Sodium ion dependence of its effect on 45Ca-efflux in guinea-pig taenia coli.
- Mechanisms of inhibitory action of phenylephrine in guinea-pig taenia coli.
- Cholecystokinin antagonism by .BETA.-carboline esters in the central nervous system in mice.
- 2-Deoxy-d-(14C)-glucose study of the interaction of caerulein and apomorphine.
- .BETA.-Carbolines selectively antagonize the cholecystokinin action in isolated guinea-pig gallbladder muscle.