EFFECTS OF HIGH POTASSIUM DEPOLARIZATION, CARBACHOL AND OXYTOCIN ON THE LANTHANUM-RESISTANT <SUP>45</SUP>Ca FRACTION IN RAT MYOMETRIUM
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概要
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The effects of high potassium, carbachol and oxytocin on <SUP>40</SUP>Ca-<SUP>45</SUP>Ca exchange in the estradiol-treated rat uterine longitudinal muscle were compared with those in the ovariectomized one using the modified “Lanthanum Method.” The treatment of estrogenized or ovariectomized myometrium with 60 mM K<SUP>+</SUP> significantly increased the <SUP>45</SUP>Ca space at 5-, 10-, 30 and 60-min incubation times. The increase in the <SUP>45</SUP>Ca by high-K<SUP>+</SUP> in the estrogenized myometrium was much greater than that in the ovariectomized one. Carbachol (2×10<SUP>-6</SUP> M) had little influence on the <SUP>45</SUP>Ca space at all incubation periods with the exception of the 10-min one in both uteri. The higher concentration of carbachol (2×10<SUP>-4</SUP> M) in the estrogenized myometrium produced a marked increase in the <SUP>45</SUP>Ca space after the 10-min incubation, while in the ovariectomized uterus, a slight increase in the <SUP>45</SUP>Ca space was observed at the 10- and 30-min incubation times. The increase in the <SUP>45</SUP>Ca space by 2×10<SUP>-4</SUP>M carbachol in the estrogenized myometrium was greater than that in the ovariectomized one. Oxytocin (10<SUP>-4</SUP> and 10<SUP>-3</SUP> units/ml) increased the <SUP>45</SUP>Ca space at and after the 10-min incubation times in the estrogenized uterus, while in the ovariectomized uterus, oxytocin (10<SUP>-3</SUP> and 10<SUP>-2</SUP> units/ml) showed little influence on the increase in the <SUP>45</SUP>Ca space. The increase in <SUP>45</SUP>Ca space by carbachol and oxytocin was inhibited by papaverine. These results suggest that differences in dependence upon Ca<SUP>2+</SUP> in the medium may exist in contractions induced by high-K<SUP>+</SUP>, carbachol and oxytocin in the uterine smooth muscle and that the contractions in the estradiol-treated myometrium may be more dependent upon extracellular Ca<SUP>2+</SUP> than those in the ovariectomized one.
- 社団法人 日本薬理学会の論文
著者
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Uruno Tsutomu
Department Of Pharmacology Faculty Of Pharmaceutical Science Science University Of Tokyo
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Uruno Tsutomu
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Matsuoka Yutaka
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Kubota Kazuhiko
Department Of Pharmacology Faculty Of Pharmaceutical Science Science University Of Tokyo
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Sekiguchi Teruyuki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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SUNAGANE NOBUYOSHI
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Science University of Tokyo
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Sunagane Nobuyoshi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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