Characteristics of antinociception induced by noncatecholic phenylethylamine derivatives: The relation of endogenous norepinephrine to phenylethylamine analog-induced antinociception.
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概要
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Characteristics of the antinociceptive action of phenylethylamine derivatives, amphetamine, β-phenylethylamine (PEA) and β-hydroxyphenylethylamine (OHPEA), were examined. The pain threshold of mice was measured by using the hot plate method. Intraperitoneal administration of α-methyl-p-tyrosine inhibited antinociception induced by PEA and OHPEA, and intracisternal administration of norepinephrine increased antinociception induced by PEA and OHPEA. Intracisternal administration of phentolamine inhibited the antinociception induced by PEA derivatives. The levels of norepinephrine and normetanephrine in the brain were determined by using H PLC. PEA derivatives decreased norepinephrine in the brain and tended to increase normetanephrine at 15 min after the administration of PEA derivatives. These findings indicate that PEA derivatives cause the release of norepinephrine in the central nervous system, and the released norepinephrine induces antinociception.
- 公益社団法人 日本薬理学会の論文
著者
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Sakuma Masafumi
Department Of Internal Medicine (cardiology Division) Iwate Medical University
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Uruno Tsutomu
Department Of Pharmacology Faculty Of Pharmaceutical Science Science University Of Tokyo
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Matsuoka Yutaka
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Kubota Kazuhiko
Department Of Pharmacology Faculty Of Pharmaceutical Science Science University Of Tokyo
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TERAWAKI Yasufumi
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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SUGIOKA Toshihiko
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Science University of Tokyo
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