2S,3R 3-Amino-2-hydroxy-4-phenylbutanoic acid derivatives, enkephalinase inhibitors, augment met5-enkephalin-induced antinociception.
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概要
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It has been accepted that the periaqueductal gray matter of the mid brain (PAG) and the reticular formation of the medulla oblongata in the brain stem have antinociceptive roles in the pain control pathways of mammals, and met<SUP>5</SUP>-enkephalin may act as one of the pain control substances in those regions. In the present study, the effects of 2S, 3R 3-amino-2-hydroxy-4-phenylbutanoic acid (AHPA) derivatives on met<SUP>5</SUP>-enkephalin-induced antinociception were examined by a hot plate method in mice. The elevation of pain threshold induced by an intracisternal administration of met<SUP>5</SUP>-enkephalin was enhanced by AHPA derivatives. The rank order of potency for these agents was as follows: bestatin>D-Phe-AHPA>AHPA-D-AIa>p-OH-AHPA-D-Phe>AHPA. This order was roughly correlated to that of the enkephalinase inhibitory activity of the AHPA derivatives. These results indicate that the inhibition of enkephalinase may produce the augumentation of the exogenous met<SUP>5</SUP>-enkephalin-induced antinociception. It is also suggested that AH PA derivatives may cause the enhancement of the endogenous met<SUP>5</SUP>-enkephalin-mediated antinociception.
- 公益社団法人 日本薬理学会の論文
著者
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Uruno Tsutomu
Department Of Pharmacology Faculty Of Pharmaceutical Science Science University Of Tokyo
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Matsuoka Yutaka
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Kubota Kazuhiko
Department Of Pharmacology Faculty Of Pharmaceutical Science Science University Of Tokyo
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Satoh Shin-ichi
Department Of Applied Molecular Biosciences Graduate School Of Bioagricultural Sciences Nagoya Unive
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SATOH SHIN-ICHI
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Science University of Tokyo
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