CHARACTERISTIC OF ANTINOCICEPTIVE EFFECT OF A TETRAPEPTIDE, Asn-Ala-Gly-Ala (NAGA)
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概要
- 論文の詳細を見る
The characteristic of the antinociceptive effect of a tetrapeptide, Asn-Ala-Gly-Ala (NAGA), was examined. Intracisternal (i. cist.) administration of NAGA to mice produced does-dependent and long-lasting antinociceptive effect as evaluated by the hot plate and tail flick methods. NAGA-induced antinociception was reversed by naloxone (2 mg/kg), reserpine (2 mg/kg×2 d) and α-methyl-p-tyrosine (100 mg/kg). NAGA (10 μM) did not significantly affect the actions of opioid peptides on the electrically evoked twitches of the myenteric plexus-longitudinal muscle strips from the guinea-pig esophagus and strips of the mouse vas deferens. NAGA-induced antinociception was scarcely affected by p-chloro-phenylalanine (PCPA, 300 mg/kg×2 d) and methysergide (2 mg/kg). From the above results, it was suggested that the antinociceptive effect of NAGA may involve the participation of endogenous opioid peptides and endogenous catecholamines.
- 公益社団法人日本薬学会の論文
著者
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Ueki Masaaki
Department Of Anesthesiology And Emergency Medicine Kagawa Medical University
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Uruno T
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Uruno Tsutomu
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Satoh Shin-ichi
ULSI Laboratory, Mitsubishi Electric Corporation
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Matsuoka Y
Ntt Photonics Laboratories
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SATOH Shin-ichi
Department of Internal Medicine, Bibai Rohsai Hospital
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Satoh S
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Kubota Kazuhiko
東京理科大学 薬
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MATSUI SHIN-ICHI
Central Research Laboratories, Asahi Breweries Ltd.
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Satoh Shin-ichi
Department Of Applied Molecular Biosciences Graduate School Of Bioagricultural Sciences Nagoya Unive
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Matsui S
Central Research Laboratories Asahi Breweries Ltd.
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Ueki Masaaki
Department of Anesthesia, Nishiwaki Municipal Hospital:Department of Anesthesia and Perioperative Medicine, Kobe University
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Ueki Masaaki
Department of Applied Chemistry, Faculty of Science, Science University of Tokyo
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UEKI Masaaki
Department of Anesthesia, Nishiwaki Municipal Hospital
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