Urinary Trypsin Inhibitor Reduces Inflammatory Response in Kidney Induced by Lipopolysaccharide(GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING)
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概要
- 論文の詳細を見る
Human urinary trypsin inhibitor (UTI), a serine protease inhibitor, has been widely used in Japan as a drug for patients with acute inflammatory disorders such as septic shock and pancreatitis. Lipopolysaccharide (LPS) triggers the sepsis syndrome by activating monocytes to produce proinflammatory cytokines, including tumor necrosis factor alpha (TNFα), which potently stimulate the activation of neutrophils. The inhibitory mechanism of UTI on the systemic inflammatory response induced by the intraperitoneal injection of LPS in the kidney is unclear. This study was undertaken to examine the inhibitory effects of UTI on renal injury associated with the systemic inflammatory response induced by LPS stimulation, with emphasis on systemic TNFα and the activation of neutrophils in rat kidney. The systemic inflammatory response syndrome was induced by LPS treatment. Serum and renal TNFα, renal cytokine-induced neutrophil chemoattractant-1 (CINC-1) and myeloperoxidase (MPO) levels, as well as renal function after LPS stimulation, were evaluated. UTI (50, 000U/kg) inhibited LPS-induced increases in the serum and renal tissue levels of TNFα, as well as the renal tissue levels of CINC-1 and MPO after LPS stimulation. UTI (50, 000U/kg) also inhibited the production of serum TNFα associated with the systemic inflammatory response syndrome induced by LPS stimulation, thereby attenuating neutrophil infiltration into renal tissues and subsequent neutrophil-mediated renal injury. These findings may have important implications in understanding the biologic functions of UTI. UTI may prove useful in protecting against acute renal injury associated with a systemic inflammatory response.
- 社団法人日本生物工学会の論文
- 2007-10-25
著者
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MAEKAWA Nobuhiro
Department of Physics, Nagoya University
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Chujo Kousuke
Department of Anesthesiology, Faculty of Medicine, Kagawa University
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Asaga Takehiko
Department of Anesthesiology, Faculty of Medicine, Kagawa University
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Ueki Masaaki
Department of Anesthesiology, Faculty of Medicine, Kagawa University
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Ueki Masaaki
Department Of Pathology And Host Defense Faculty Of Medicine Kagawa University
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Ueki Masaaki
Department Of Anesthesiology And Emergency Medicine Kagawa Medical University
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Chujo Kousuke
Department Of Anesthesiology Faculty Of Medicine Kagawa University
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Asaga Takehiko
Department Of Anesthesiology Faculty Of Medicine Kagawa University
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Maekawa Nobuhiro
Department Of Anesthesia And Perioperative Medicine Kobe University Hospital
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Taie Satoshi
Department of Anesthesiology & Emergency Medicine, Faculty of Medicine, Kagawa University
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Ono Junichiro
Department of Anesthesiology and Emergency Medicine, Faculty of Medicine, Kagawa University
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Iwanaga Yasuyuki
Department of Anesthesiology and Emergency Medicine, Faculty of Medicine, Kagawa University
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Ono Junichiro
Department Of Anesthesiology And Emergency Medicine Kagawa University School Of Medicine
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Ono Junichiro
Department Of Anesthesiology And Emergency Medicine Kagawa Medical University
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Taie Satoshi
Department Of Anesthesiology And Emergency Medicine Kagawa University School Of Medicine
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Iwanaga Yasuyuki
Department Of Anesthesiology And Emergency Medicine Kagawa University School Of Medicine
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Maekawa Nobuhiro
Department Of Anesthesia And Perioperative Medicine Kobe University
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MAEKAWA Nobuhiro
Departinrnt of Physics, Kyoto University
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Ueki Masaaki
Department of Anesthesia, Nishiwaki Municipal Hospital:Department of Anesthesia and Perioperative Medicine, Kobe University
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UEKI Masaaki
Department of Anesthesia, Nishiwaki Municipal Hospital
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