JTE-607, an Inflammatory Cytokine Synthesis Inhibitor, Attenuates Ischemia/Reperfusion-Induced Renal Injury by Reducing Neutrophil Activation in Rats(GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING)

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概要

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• Renal ischemia/reperfusion (I/R) injury is one of the main causes of postoperative renal failure. Activated neutrophils are implicated in the development of I/R-induced renal failure. JTE-607 has been reported to be a potent inhibitor of the multiple inflammatory cytokines in the endotoxic shock mouse model and heart Langendorff perfusion model. In this study, we examined whether JTE-607 attenuates I/R-induced renal injury by reducing neutrophil activation. Male wistar rats were intravenously administered JTE-607 (JTE group, 30mg/kg) or 5% mannitol (control group) 30min before ischemia. JTE-607 reduced the I/R-induced increases in the serum concentrations of blood urea nitrogen and creatinine, and improved the histopathologic changes, including acute tubular necrosis. I/R-induced an increase in neutrophil activation, reflected by increases in renal cytokine-induced neutrophil chemoattractant (CINC)-1 and myeloperoxidase (MPO) concentrations which were significantly reduced by JTE-607. These findings indicate that JTE-607 attenuates I/R-induced acute renal injury, probably by inhibiting neutrophil activation. JTE-607 might be a novel therapeutic strategy for the protection of postoperative renal failure in surgery associated with renal ischemia as well as renal transplantation.

• 2008-07-25

著者

• Chujo Kousuke

  Department of Anesthesiology, Faculty of Medicine, Kagawa University

• Asaga Takehiko

  Department of Anesthesiology, Faculty of Medicine, Kagawa University

• Ueki Masaaki

  Department of Anesthesiology, Faculty of Medicine, Kagawa University

• Ueki Masaaki

  Department Of Pathology And Host Defense Faculty Of Medicine Kagawa University

• Ueki Masaaki

  Department Of Anesthesiology And Emergency Medicine Kagawa Medical University

• Chujo Kousuke

  Department Of Anesthesiology Faculty Of Medicine Kagawa University

• Asaga Takehiko

  Department Of Anesthesiology Faculty Of Medicine Kagawa University

• Taie Satoshi

  Department of Anesthesiology & Emergency Medicine, Faculty of Medicine, Kagawa University

• Taie Satoshi

  Department Of Anesthesiology And Emergency Medicine Kagawa University School Of Medicine

• Ueki Masaaki

  Department of Anesthesia, Nishiwaki Municipal Hospital:Department of Anesthesia and Perioperative Medicine, Kobe University

• UEKI Masaaki

  Department of Anesthesia, Nishiwaki Municipal Hospital

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