Phosphinyl- and phosphinothioylamino acids and peptides. VIII. New practical removal conditions for the S-Mpt group and their application for the synthesis of bis(N,N-diallyl-(D-Ala2,L-Leu5)-enkephalyl)cystine.
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概要
- 論文の詳細を見る
Synthesis of bis[<I>N</I>,<I>N</I>-diallyl-[D-Ala<SUP>2</SUP>, L-Leu<SUP>5</SUP>]-enkephalyl]cystine, which is expected to be a selective opioid δ-receptor antagonist, was studied. The mercapto group of cysteine was protected by the dimethylphosphinothioyl(Mpt) group. For the removal of this group without damaging the allyl moiety, new mild removal conditions by use of KF/18-crown-6 in a solvent mixture of acetonitrile–methanol are proposed. Bis[D-Ala<SUP>2</SUP>, L-Leu<SUP>5</SUP>]-enkephalyl]cystine was also prepared in a similar manner.
- 公益社団法人 日本化学会の論文
著者
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UEKI Masaaki
Department of Applied Chemistry, Science University of Tokyo
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Ueki Masaaki
Department of Anesthesia, Nishiwaki Municipal Hospital:Department of Anesthesia and Perioperative Medicine, Kobe University
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SHINOZAKI Kozo
Department of Applied Chemistry, Science University of Tokyo
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