Phosphinyl- and phosphinothioylamino acids and peptides. V. Preparation of dimethylphosphinothioylamino acids and solid phase peptide synthesis.
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概要
- 論文の詳細を見る
The use of the dimethylphosphinothioyl(Mpt) group for protection of <I>N</I><SUP>α</SUP>-amino functions of amino acids has been studied as the most readily removable group in the phosphinothioyl series. The Mpt-amino acids have been prepared by the alkaline hydrolysis of Mpt-amino acid esters and Schotten-Baumann type reactions of free amino acids. The Mpt group has been removed using a solution of triphenylphosphine dihydrochloride in dichloromethane. L-Leu<SUP>5</SUP>- and D-Ala<SUP>2</SUP>, L-Leu<SUP>5</SUP>-enkephalins have been synthesized by a solid phase method and synthetic L-Leu<SUP>5</SUP>-enkephalin exibited identical activity with an authentic sample.
- 公益社団法人 日本化学会の論文
著者
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Inazu Toshiyuki
Department Of Applied Chemistry School Of Engineering Tokai University
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IKEDA Shigeru
Department of Computer and Mathematical Sciences, Graduate School of Information Sciences, Tohoku Un
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Ueki Masaaki
Department of Anesthesia, Nishiwaki Municipal Hospital:Department of Anesthesia and Perioperative Medicine, Kobe University
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