D-Allose Protects Against Endotoxemic Acute Renal Injury(GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING)
スポンサーリンク
概要
- 論文の詳細を見る
D-Allose is a monosaccharide. We previously reported that D-allose attenuated renal injury by inhibiting the activation of neutrophils after renal ischemia/reperfusion. Lipopolysaccharide(LPS) triggers sepsis syndrome by activating monocytes to produce proinflammatory cytokines, including tumor necrosis factor(TNF)-alpha, which potently stimulates the activation of neutrophils. This study was undertaken to examine the effects of D-allose on renal injury in the systemic inflammatory response induced by LPS administration, with emphasis on systemic TNF-alpha and the activation of neutrophils in the rat kidney. Serum and renal TNF-alpha, renal cytokine-induced neutrophil chemoattractant(CINC)-1, and myeloperoxidase(MPO) concentrations, and renal function after LPS administration were evaluated. D-Allose(400 mg/kg body weight) inhibited LPS-induced increases in serum and renal TNF-alpha concentrations and renal CINC-1 and MPO concentrations after LPS administartion, as well as the subsequent neutrophil-mediated renal injury. These findings may have important implications in understanding the biologic functions of D-allose. D-Allose may prove useful in protecting against acute renal injury in systemic inflammatory responses to LPS.
- 2008-05-25
著者
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Chujo Kousuke
Department of Anesthesiology, Faculty of Medicine, Kagawa University
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Asaga Takehiko
Department of Anesthesiology, Faculty of Medicine, Kagawa University
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Ueki Masaaki
Department of Anesthesiology, Faculty of Medicine, Kagawa University
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Ueki Masaaki
Department Of Pathology And Host Defense Faculty Of Medicine Kagawa University
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Ueki Masaaki
Department Of Anesthesiology And Emergency Medicine Kagawa Medical University
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Chujo Kousuke
Department Of Anesthesiology Faculty Of Medicine Kagawa University
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Asaga Takehiko
Department Of Anesthesiology Faculty Of Medicine Kagawa University
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Taie Satoshi
Department of Anesthesiology & Emergency Medicine, Faculty of Medicine, Kagawa University
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Ono Junichiro
Department of Anesthesiology and Emergency Medicine, Faculty of Medicine, Kagawa University
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Iwanaga Yasuyuki
Department of Anesthesiology and Emergency Medicine, Faculty of Medicine, Kagawa University
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Ono Junichiro
Department Of Anesthesiology And Emergency Medicine Kagawa University School Of Medicine
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Ono Junichiro
Department Of Anesthesiology And Emergency Medicine Kagawa Medical University
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Taie Satoshi
Department Of Anesthesiology And Emergency Medicine Kagawa University School Of Medicine
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Iwanaga Yasuyuki
Department Of Anesthesiology And Emergency Medicine Kagawa University School Of Medicine
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Ueki Masaaki
Department of Anesthesia, Nishiwaki Municipal Hospital:Department of Anesthesia and Perioperative Medicine, Kobe University
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UEKI Masaaki
Department of Anesthesia, Nishiwaki Municipal Hospital
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