Inhibitory Effect of D-Allose on Neutrophil Activation after Rat Renal Ischemia/Reperfusion(GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING)

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概要

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• D-Allose is one of the rare sugars produced from D-psicose. We examined whether D-allose reduces the extent of rat renal ischemia/reperfusion (I/R) injury by suppressing the activation of neutrophils. The renal concentrations of cytokine-induced neutrophil chemoattractant (CINC)-1 and myeloperoxidase were significantly increased after renal I/R. These increases were significantly inhibited by D-allose administration. Furthermore, D-allose significantly inhibited the increase in the concentrations of blood urea nitrogen (BUN), creatinine, N-acetyl β-D-glucosaminidase (NAG) and histopathologic changes after renal I/R. These findings strongly suggest that D-allose protects against I/R-induced renal injury by inhibiting the activation of neutrophils that play an important role in I/R-induced renal injury. These findings may have important implications in understanding the biologic functions of D-allose. D-Allose may prove useful in renal surgery and transplantation.

• 社団法人日本生物工学会の論文
• 2007-10-25

著者

• MAEKAWA Nobuhiro

  Department of Physics, Nagoya University

• Chujo Kousuke

  Department of Anesthesiology, Faculty of Medicine, Kagawa University

• Asaga Takehiko

  Department of Anesthesiology, Faculty of Medicine, Kagawa University

• Ueki Masaaki

  Department of Anesthesiology, Faculty of Medicine, Kagawa University

• Ueki Masaaki

  Department Of Pathology And Host Defense Faculty Of Medicine Kagawa University

• Ueki Masaaki

  Department Of Anesthesiology And Emergency Medicine Kagawa Medical University

• Chujo Kousuke

  Department Of Anesthesiology Faculty Of Medicine Kagawa University

• Asaga Takehiko

  Department Of Anesthesiology Faculty Of Medicine Kagawa University

• Maekawa Nobuhiro

  Department Of Anesthesia And Perioperative Medicine Kobe University Hospital

• Taie Satoshi

  Department of Anesthesiology & Emergency Medicine, Faculty of Medicine, Kagawa University

• Iwanaga Yasuyuki

  Department of Anesthesiology and Emergency Medicine, Faculty of Medicine, Kagawa University

• Taie Satoshi

  Department Of Anesthesiology And Emergency Medicine Kagawa University School Of Medicine

• Iwanaga Yasuyuki

  Department Of Anesthesiology And Emergency Medicine Kagawa University School Of Medicine

• Maekawa Nobuhiro

  Department Of Anesthesia And Perioperative Medicine Kobe University

• MAEKAWA Nobuhiro

  Departinrnt of Physics, Kyoto University

• Ueki Masaaki

  Department of Anesthesia, Nishiwaki Municipal Hospital:Department of Anesthesia and Perioperative Medicine, Kobe University

• UEKI Masaaki

  Department of Anesthesia, Nishiwaki Municipal Hospital

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