REVERSAL OF ANTINOCICEPTIVE EFFECT OF CAERULEIN BY BENZODIAZEPINE
スポンサーリンク
概要
- 論文の詳細を見る
Benzodiazepines, chlordiazepoxide and diazepam reversed the antinociceptive action of caerulein in mice. Benzodiazepines (1-5 mg/kg) were administrated intraperitoneally and 100 ng of caerulein was injected intracisternally to mice. Benzodiazepines did not change the basal pain threshold of mice but significantly antagonized the antinociceptive effect of caerulein. Proglumide (200 mg/kg, i.p.), which has been claimed to be a specific cholecystokinin receptor antagonist, could also antagonize the antinociceptive effects of caerulein. Naloxone (5 mg/kg) partially but significantly antagonized the antinociceptive effect of caerulein, suggesting that one of the mechanisms of antinociceptive action of caerulein is related to endogeous opioid peptides since benzodiazepines do not act on opioid receptors. Benzodiazepines may decrease the antinociceptive effect of caerulein through acting on cholecystokinin receptors in the central nervous system.
- 公益社団法人日本薬学会の論文
著者
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Kubota Kazuhiko
Department Of Pharmacology Faculty Of Pharmaceutical Science Science University Of Tokyo
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Kubota K
Research Institute For Biology & Chemistry Tsumura & Co.
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Kubota Kazuhiko
東京理科大学 薬
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SUNAGANE NOBUYOSHI
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Science University of Tokyo
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Sunagane N
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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SUN FENGYAN
Department of Neurobiology, Shanghai First Medical College
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Sun Fengyan
Department Of Neurobiology Shanghai First Medical College
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Sugaya Kiminobu
Department Of Psychiatry The Psychiatric Institute University Of Illinois At Chicago
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Sunagane Nobuyoshi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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