Inhibition of hypothermic effect of cholecystokinin by benzodiazepines and a benzodiazepine antagonist, Ro 15-1788, in mice.
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概要
- 論文の詳細を見る
Intracisternally administered cholecystokinin produced long lasting hypothermia in mice, and the hypothermic effect was significantly antagonized by benzodiazepines like chlordiazepoxide and diazepam and by a benzodiazepine antagonist, Ro 15-1788, that were administered 1ntraperitonea Ily. Proglumide, a cholecystokinin antagonist, failed to prevent the hypothermia induced by cholecystokinin at a dose of 200 mg/kg. Benzodiazepines and Ro 15-1788 revealed a considerably strong hypothermic effect, but they still prevented the hypothermic effect of cholecystokinin. The precise mechanism of the antagonism between cholecystokinin and benzodiazepines remains unclear at present.
- 公益社団法人 日本薬理学会の論文
著者
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Kubota Kazuhiko
Department Of Pharmacology Faculty Of Pharmaceutical Science Science University Of Tokyo
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SUGAYA Kiminobu
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Science University of Tokyo
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MATSUDA Ikuko
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Science University of Tokyo
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