Effects of Z-300, a New Histamine H2-Receptor Antagonist, on Mucin Biosynthesis in Rat Gastric Mucosa.
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概要
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We examined the effects of Z-300 (<I>N</I>-[3-[3-(piperidinomethyl)phenoxy]propyl]-2-(2-hydroxy-ethyl-1-thio)acetamido·2-(4-hydroxy benzoyl)benzoate), a newly-synthesized selective histamine H<SUB>2</SUB>-receptor antagonist, on mucin in rat gastric mucosa. Deep corpus mucin content increased significantly to 127% of the control after the administration of 30 mg/kg of Z-300, whereas that in the antral mucosa did not in crease. The addition of Z-300 significantly increased [<SUP>3</SUP>H]-labeled mucin in the corpus region. In the antrum, biosynthetic activity showed no significant change by 10<SUP>-8</SUP>-10<SUP>-5</SUP>M of Z-300. These results suggest that Z-300 not only inhibits acid secretion but may also promote gastric mucus metabolism in the corpus region.
- 公益社団法人 日本薬理学会の論文
著者
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Hotta Kyoko
Department Of Biochemistry Kitasato University School Of Medicine
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Ohara Susumu
Department Of Biochemistry Kitasato University School Of Medicine
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Saigenji Katsunori
Department Of Gastroenterology Kitasato University Hospital
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Ishihara Kazuhiko
Department Of Biochemistry Kitasato University Graduate School Of Medical Sciences
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Ogata Yumi
Departments Of Internal Medicine Kitasato University School Of Medecine.
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Ichikawa Takafumi
Department Of Biochemistry Kitasato University School Of Allied Health Sciences
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Saigenji Katsunori
Departments of Internal Medicine, Kitasato University School of Medicine
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Ogata Yumi
Departments of Internal Medicine, Kitasato University School of Medicine
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HOTTA Kyoko
Department of Biochemistry and Internal Medicine, Kitasato University School of Medicine
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Ohara Susumu
Departments of Biochemistry, Kitasato University School of Medicine
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Ichikawa Takafumi
Departments of Biochemistry, Kitasato University School of Medicine
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