Anti-inflammatory Effect of Spironolactone on Human Peripheral Blood Mononuclear Cells
スポンサーリンク
概要
- 論文の詳細を見る
We evaluated the effect of alacepril, CV-11974, and spironolactone on the production of monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-α) in cultured human peripheral blood mononuclear cells stimulated with angiotensin (Ang) II. Alacepril, CV-11974, and spironolactone significantly reduced the enhanced production of MCP-1 and TNF-α induced by exogenous Ang II. Specifically, 10 μM of spironolactone significantly reduced cytokine production, compared to the same dose of alacepril or CV-11974. These findings indicate that spironolactone may contribute to ameliorate the prognosis of patients with cardiovascular diseases by reducing Ang II-induced inflammation, although further exploration including determining the mechanisms would be required.
- 公益社団法人 日本薬理学会の論文
著者
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Hisamatsu Kenichi
Department Of Cardiology National Hospital Organization Okayama Medical Center
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Miura Aya
Department Of Cardiovascular Medicine Okayama University Graduate School Of Medicine Dentistry And P
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Ishihara Kazuhiko
Department Of Biochemistry Kitasato University Graduate School Of Medical Sciences
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Miura Daiji
Department Of Cardiovascular Medicine Okayama University Graduate School Of Medicine Dentistry And P
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Kajiya Masahito
Department Of Cardiology The Heart Institute Of Japan Tokyo Women's Medical University
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Morita Hiroshi
Department Of Applied Chemistry School Of Engineering Kanagawa University
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Miura Ryuzea
Department Of Cardiovascular Medicine Okayama University Graduate School Of Medicine Dentistry And P
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Ohe Tohru
Department Of Cardiology Okayama University
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Fukushima Kusano
Department Of Cardiovascular Medicine Okayama University
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Miura Aya
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
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Nakamura Kazufumi
Department of Applied Chemistry, Faculty of Science and Technology, Keio University
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Nagase Satoshi
Department of Cardiology, Okayama University Graduate School of Medicine
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Fukushima Kusano
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
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Miura Ryuzea
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
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Kajiya Masahito
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
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Nakamura Kazufumi
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
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Miura Daiji
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
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Morita Hiroshi
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
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