Change of Cathepsin D Activity Recognized in Granulocytes from Patients with Carcinomas of the Gastrointestinal Tract
スポンサーリンク
概要
- 論文の詳細を見る
The role of granulocytes attracts attention in the host defense mechanism against tumor cells because granulocytes have cytostatic and cytotoxic activity against tumor cells. In the mechanism of granulocyte-mediated tumor cell destruction, lysosomes in granulocytes may be considered to play an important role. From this view point, the change of cathepsin D activity in granulocytes from patients with carcinomas of the gastrointestinal tract (GI carcinoma) in different performance status and different immunological status was investigated in order to evaluate whether or not the change of this enzyme activity correlates to the immune responsiveness of carcinoma-bearing patients. Our experimental results indicate that the change of the free and total cathepsin D activities in granulocytes was correlated to the immunological parameters in patients with GI carcinoma. The cathepsin D activity in granulocytes is evaluated as an available parameter to reflect the immune responsiveness in patients with GI carcinoma, though the change of this enzyme activity is not considered to be specific in patients with GI carcinoma.
- 北里大学の論文
- 1992-02-29
著者
-
Saigenji Katsunori
Department Of Gastroenterology Kitasato University Hospital
-
Maekawa Kimio
Department of Internal Medicine, Kitasato University School of Medicine
-
Taniguchi Takesi
Department of Internal Medicine, Kitasato University School of Medicine
-
Ohno Takasi
Department of Internal Medicine, Kitasato University School of Medicine
関連論文
- Inoperable Advanced Gastric Cancer : A Study in Retrospect Covering 13 Years at Kitasato University Hospital
- Role of endogenous substance P in ethanol-induced mucosal damage in the rat stomach
- Hepatoid adenocarcinoma in Barrett's esophagus associated with achalasia : First case report
- Hepatitis A Virus Infection Associated with Hemophagocytic Syndrome : Report of Two cases
- Efficacy of Continuous Regional Arterial Infusion of a Protease Inhibitor and Antibiotic for Severe Acute Pancreatitis in Patients Admitted to an Intensive Care Unit
- A Case of Advanced Esophageal Carcinoma with a Prolonged Complete Response to Chemoradiotherapy
- Intrahepatic distant recurrence after radiofrequency ablation for a single small hepatocellular carcinoma : risk factors and patterns
- Risk factors of delay in restoration of hepatic reserve capacity and local recurrence after radiofrequency ablation therapy for hepatocellular carcinoma (HCC)
- Diagnostic efficacy of superparamagnetic iron oxide enhanced MR (SPIO-enhanced MR) imaging for the effectiveness of radiofrequency ablation for hepatocellular carcinoma : comparison with helical CT
- Occult hepatitis B virus infection as a risk factor for hepatocellular carcinoma in patients with chronic hepatitis C in whom viral eradication fails
- Roles of calcitonin gene-related peptide and prostaglandin I_2 in prevention of ethanol-induced gastric mucosal microcirculatory disturbances by mild irritant in rats
- Suppression of Dextran Sulfate Sodium-Induced Colitis in Kininogen-Deficient Rats and Non-peptide B_2 Receptor Antagonist-Treated Rats
- Compensatory response of colon tissue to dextran sulfate sodium-induced colitis
- Effects of 2-[(2-Dimethylaminobenzyl) Sulfinyl] Benzimidazole, the Proton-Pump Inhibitor, on Rat Gastric Mucins with HC1-Ethanol-Induced Gastric Damage
- Effects of Acid Secretagogues or HC1 on Rat Gastric Mucins
- Cyclooxygenase-2 Inhibitors Attenuate Increased Blood Pressure in Renovascular Hypertensive Models, but Not in Deoxycorticosterone-Salt Hypertension
- Spraying of phenol red dye as a screening test for Helicobacter pylori infection in surgically resected stomach specimens
- Thrombotic thrombocytopenic purpura in autoimmune hepatitis
- Recovery of mucin content in surface layer of rat gastric mucosa after HCI-aspirin-induced mucosal damage
- Mucosal Protection by Shokyo, a Crude Drug, against Ethanol-induced Gastric Damage in Rat
- SURVEILLANCE BY MAGNIFYING ENDOSCOPY IN PATIENTS WITH ULCERATIVE COLITIS
- Significant correlation of morphological remodeling in ulcerative colitis with disease duration and between elevated p53 and p21^ expression in rectal mucosa and neoplastic development
- Therapeutic benefits of partial splenic embolization for thrombocytopenia in hepatocellular carcinoma patients treated with radiofrequency ablation
- Genetic instability on chromosome 17 in the epithelium of non-polypoid colorectal carcinomas compared to polypoid lesions
- CLINICAL ROLE OF ENDOSCOPIC ULTRASONOGRAPHY FOR THE DIAGNOSIS OF EARLY COLORECTAL CANCER AND SELECTING THE TREATMENT PROCEDURE
- BROADENING INDICATIONS FOR ENDOSCOPIC TREATMENT OF EARLY COLORECTAL CANCER
- Intestinal Behcet's disease : pathognomonic changes in intramucosal lymphoid tissues and effect of a"rest cure"on intestinal lesions
- Hyperglycemia-induced Alteration in Proteomes of the Rat Renal Cortex
- Liver abscess that responded well to pazufloxacin therapy
- Effects of indomethacin on the rat small intestinal mucosa : immunohistochemical and biochemical studies using anti-mucin monoclonal antibodies
- EARLY COMPLICATIONS OF ENDOSCOPIC SPHINCTEROTOMY FOR COMMON BILE DUCT STONES
- ENODSCOPIC MUCOSAL RESECTION FOR GASTRIC CANCER : NECESSITY OF 'INCISION AND STRIPPING METHOD' AND PRESENT STATUS
- EOSINOPHILIC GASTROENTERITIS ASSOCIATED WITH GIANT FOLDS
- RECTAL GRANULAR-CELL TUMOR DIFFICULT TO DISTINGUISH FROM CARCINOID TUMOR
- Is intestinal Behcet's disease in fact an enterocolitis or an ulcer disease, and is steroid treatment useful or harmful?
- Severe chronic active Epstein-Barr virus infection associated with multiple necrotic lesions in the liver
- Change of Cathepsin D Activity Recognized in Granulocytes from Patients with Carcinomas of the Gastrointestinal Tract
- Effects of Z-300, a New Histamine H2-Receptor Antagonist, on Mucin Biosynthesis in Rat Gastric Mucosa.
- Appearance of specific mucins recognized by monoclonal antibodies in rat gastric mucosa healing from HCl-induced gastric mucosal damage