EFFECT OF GERANYLGERANYLACETONE ON ASPIRIN-INDUCED CHANGES IN GASTRIC GLYCOPROTEINS

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概要

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• The effects of aspirin and treatment with geranylgeranylacetone (GGA), an antiulcer drug, on the content of gastric glycoproteins were investigated in pylorusligated rats. In normal rats, the amount of gastric glycoproteins in the mucous layer was about 1.5 times higher than that in the gastric mucosa, indicating that the glycoproteins were distributed in the mucous layer as a highly concentrated state. Aspirin (100 mg/kg, p.o.) decreased the content of gastric glycoproteins both in the mucous layer and in the gastric mucosa. The amount of the macromolecular fraction in the gastric juice, which corresponded to the gastric glycoproteins on the basis of molecular size, was not affected by aspirin. GGA (300 mg/kg, i.d.) could prevent the decreases of the total amount of gastric glycoproteins in the mucous layer plus gastric mucosa. These results indicated that the glycoproteins coating the surface of the gastric mucosa may play a role as a defensive mechanism and that GGA exerted an antiulcer effect on aspirin-induced mucosal damage through preventing the decreases in gastric glycoproteins.

• 社団法人 日本薬理学会の論文

著者

• Murakami Manabu

  Department Of Healthcare Systems Research Graduate School Of Medicine Hokkaido University

• Hotta Kyoko

  Department Of Biochemistry Kitasato University School Of Medicine

• OKETANI Kiyoshi

  Department of Pharmacology, Tsukuba Research Laboratories, Eisai Co., Ltd.

• FUJISAKI Hideaki

  Department of Pharmacology, Tsukuba Research Laboratories, Eisai Co., Ltd.

• WAKABAYASHI Tsuneo

  Department of Pharmacology, Tsukuba Research Laboratories, Eisai Co., Ltd.

• Murakami Manabu

  Department Of Forensic Medicine Graduate School Of Medicine Hokkaido University

• MURAKAMI Manabu

  Department of Pharmacology, Tsukuba Research Laboratories, Eisai Co., Ltd.

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