The Pathological Role of Transient Receptor Potential Channels in Heart Disease
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概要
- 論文の詳細を見る
Transient receptor potential (TRP) channels are expressed in almost every human tissue, including the heart and vasculature. Most are permeable to Ca^<2+> and play unique roles as multifunctional cellular sensors. Their involvement in many fundamental cell functions (eg, contraction, proliferation, and cell death) has made investigating their roles in human disease an urgent priority for medical science. This review presents an overview of current knowledge about the pathological role of TRP channels in heart disease and highlights some TRP channels with anticipated roles in disease. Evidence suggests that (a) upregulation of TRPC channels is involved in the development of cardiac hypertrophy and heart failure; (b) TRPC1, TRPC6, and TRPV2 play a role in the pathogenesis of cardiomyopathy associated with muscular dystrophy; (c) TRPC6 or TRPM4 is involved in the delayed afterdepolarization; (d) TRPP2 is involved in the normal development of the interventricular and interatrial septa; and (e) neuronal TRPV1 acts as a detector of pain-producing stimuli. Ultimately, TRP channels might become novel pharmacological targets in the treatment of human heart disease.
- 2009-02-20
著者
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Watanabe Hiroyuki
榊原記念病院 心臓血管外科
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ONO Kyoichi
Department of Pharmacology, Akita University School of Medicine
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Ito Hiroyuki
Department Of Internal Medicine Division Of Cardiovascular And Respiratory Medicine Akita University
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Watanabe Hiroyuki
Second Department of Internal Medicine, Akita University School of Medicine
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Ito Hiroshi
Second Department of Internal Medicine, Akita University School of Medicine
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Ohba Takayoshi
Department of Cardiovascular center, Chiba-Hokusoh Hospital, Nippon Medical School
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Ohba Takayoshi
Department Of Physiology Akita University Graduate School Of Medicine
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Watanabe Hiroyuki
Department Of Cardiovascular And Respiratory Medicine Akita University Graduate School Of Medicine
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Murakami Manabu
Department of Physiology, Akita University School of Medicine
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Murakami Manabu
Department Of Physiology Akita University School Of Medicine
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Murakami Manabu
Department Of Healthcare Systems Research Graduate School Of Medicine Hokkaido University
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Ono Kyoichi
Department Of Pharmacology Akita University School Of Medicine
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Ono Kyoichi
Department Of Physiology Akita University School Of Medicine
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Ito Hiroshi
Second Department Of Internal Medicine Tokyo Medical And Dental University
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Watanabe Hiroyuki
Department Of Internal Medicine Division Of Cardiovascular And Respiratory Medicine Akita University
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Watanabe Hiroyuki
Second Department Of Internal Medicine Akita University School Of Medicine
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Ono Kyoichi
Department Of Cell Physiology Akita University Graduate School Of Medicine
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Murakami Manabu
Department Of Forensic Medicine Graduate School Of Medicine Hokkaido University
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Ohba Takayoshi
Department of Cardiology, Cardiovascular Center, Nippon Medical School Chiba-Hokusoh Hospital
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Murakami Manabu
Department of Applied Chemistry, Faculty of Engineering, Yamagata University
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