Low Molecular Weight Heparin Prevents Cardiovascular Remodeling Induced by the Long-Term Inhibition of Nitric Oxide Synthase with N-Nitro-L-Arginine Methyl Ester in Rat Hearts
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概要
- 論文の詳細を見る
To evaluate the effect of low molecular weight heparin (LMWH) oncardiovascular remodeling induced by long term inhibition of nitric oxide synthase withN-nitro-L-arginine methyl ester (L-NAME), 40 male Sprague-Dawley rats were randomlydivided into four groups: the control group (n=10) that received 0.9% saltsolution; the L-NAME group (n=10) that received 30 mg/kg/day of L-NAME, theLMWH3000 group (n=10) that received 30 mg/kg/day of L-NAME and 4 mg/kg/dayof LMWH (molecular weight (M.W.) of 3000) and the LMWH6000 group (n= 10)that received 30 mg/kg/day of L-NAME and 4 mg/kg/day of LMWH (M.W. 6000).All agents, including saline, were administered intraperitoneally by implantation ofosmotic mini pumps. Systolic blood pressure was measured by the tail-cuff method ontreatment days 1,7, 14, and 28, and histological examination of harvested cardiac tissueand coronary arteries was performed on day 28. Systolic blood pressure was greater inthe L-NAME, LMWH3000 and LMWH6000 groups when compared with the controlgroup. There were no significant differences in activated coagulation time (ACT)when comparing the four groups. Medial smooth muscle cell proliferation and hypertrophyand increases in perivascular and myocardial fibrosis were observed in the L-NAMEgroup compared with the control group. Further, these changes were inhibited by thecoadministration of LMWH3000 or LWMH6000. This study demonstrates that LMWHprevents cardiovascular remodeling induced by L-NAME in rat hearts independent of itsanticoagulant activity. Low molecular weight heparin prevents cardiovascular remodeling
- 秋田大学の論文
著者
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Iino Kenji
Department of Cardiovascular and Respiratory Medicine, Akita University Graduate School of Medicine
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Watanabe Hiroyuki
榊原記念病院 心臓血管外科
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Tosa Shinya
秋田大学 医学部内科循環器内科学
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Ishida Masaru
Department Of Internal Medicine Division Of Cardiovascular And Respiratory Medicine Akita University
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Iino Kenji
Department Of Cardiovascular And Respiratory Medicine Akita University Graduate School Of Medicine
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Kosaka Toshimitu
Department Of Cardiovascular And Respiratory Medicine Akita University Graduate School Of Medicine
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Watanabe Hiroyuki
Department Of Cardiovascular And Respiratory Medicine Akita University Graduate School Of Medicine
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Miura Mamoru
The Second Department of Internal Medicine Akita University School of Medicine
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Haswgawa Hitoshi
Department Of Internal Medicine Division Of Cardiovascular And Respiratory Medicine Akita University
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Ito Hiroshi
Department Of Cardiovascular And Respiratory Medicine Akita University Graduate School Of Medicine
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Miura Mamoru
The Second Department Of Internal Medicine Akita University School Of Medicine Akita.
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Hasegawa Hitoshi
Second Dept. Of Internal Medicine Akita University
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Miura Mamoru
The 2nd Depertment Of Internal Medicine Akita University
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Takahashi Satoru
The Second Department Of Internal Medicine Akita University School Of Medicine Akita.
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Miura Mamoru
Second Dept. Of Internal Medicine Akita University
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Fujiwara Yosimasa
2nd Department Of Internal Medicine Akita University School Of Medicine.
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Miura Hiroto
Second Dept.of Internal Medicine Akita University
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Sato Tadaya
Division Of Cardiology Akita Medical Center
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Saito Takashi
Second Dept.of Internal Medicine Akita University
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Miura Mamoru
The 2nd Department Of Intemal Medicine Akita University School Of Medicine
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Miura Mamoru
Second Dept.of Internal Medicine Akita University
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