A New PET Scanner with Semiconductor Detectors Enables Better Identification of Intratumoral Inhomogeneity
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概要
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An autoradiography method revealed intratumoral inhomogeneity in various solid tumors. It is becoming increasingly important to estimate intratumoral inhomogeneity. However, with low spatial resolution and high scatter noise, it is difficult to detect intratumoral inhomogeneity in clinical settings. We developed a new PET system with CdTe semiconductor detectors to provide images with high spatial resolution and low scatter noise. Both phantom images and patients’ images were analyzed to evaluate intratumoral inhomogeneity. Methods: This study was performed with a cold spot phantom that had 6-mm-diameter cold sphenoid defects, a dual-cylinder phantom with an adjusted concentration of 1:2, and an ''H''-shaped hot phantom. These were surrounded with water. Phantom images and 18F-FDG PET images of patients with nasopharyngeal cancer were compared with conventional bismuth germanate PET images. Profile curves for the phantoms were measured as peak-to-valley ratios to define contrast. Intratumoral inhomogeneity and tumor edge sharpness were evaluated on the images of the patients. Results: The contrast obtained with the semiconductor PET scanner (1.53) was 28% higher than that obtained with the conventional scanner (1.20) for the 6-mm-diameter cold sphenoid phantom. The contrast obtained with the semiconductor PET scanner (1.43) was 27% higher than that obtained with the conventional scanner (1.13) for the dual-cylinder phantom. Similarly, the 2-mm cold region between 1-mm hot rods was identified only by the new PET scanner and not by the conventional scanner. The new PET scanner identified intratumoral inhomogeneity in more detail than the conventional scanner in 6 of 10 patients. The tumor edge was sharper on the images obtained with the new PET scanner than on those obtained with the conventional scanner. Conclusion: These phantom and clinical studies suggested that this new PET scanner has the potential for better identification of intratumoral inhomogeneity, probably because of its high spatial resolution and low scatter noise.
- Society of Nuclear Medicineの論文
著者
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Tamaki Nagara
台湾
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Shiga Tohru
Department Of Nuclear Medicine Hokkaido University Graduate School Of Medicine
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Nakata Tomoaki
Second Department Of Internal Medicine Sapporo Medicine University
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Tamaki Nagara
Hokkaido University School Of Medicine Department Of Tracer Kinetics And Department Of Nuclear Medic
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Katoh C
Department Of Health Science Hokkaido University Graduate School Of Medicine
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Kubo Naoki
Department Of Health Sciences School Of Medicine Hokkaido University
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Hirata Kenji
Department Of Nuclear Medicine Hokkaido University Graduate School Of Medicine
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Katoh Chietsugu
Department Of Nuclear Medicine Hokkaido University School Of Medicine
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Tamaki Nagara
Hokkaido University Nuclear Medicine
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Katoh Norio
Department Of Radiology Hokkaido University Graduate School Of Medicine
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Tamaki Nagara
Department Of Nuclear Medicine Hokkaido University School Of Medicine
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Shiga Tohru
Hokkaido University Graduate School Of Medicine Department Of Nuclear Medicine
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Tamaki Nagara
Hokkaido University School Of Medicine Department Of Tracer Kinetics And Department Of Nuclear Medic
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Sugimori Hiroyuki
Department Of Diagnostic And Interventional Radiology Hokkaido University Hospital
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Tamaki Nagara
Hokkaido University Graduate School Of Medicine Department Of Nuclear Medicine
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