[18F]fluoromisonidazole and a New PET System With Semiconductor Detectors and a Depth of Interaction System for Intensity Modulated Radiation Therapy for Nasopharyngeal Cancer
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概要
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Purpose: The impact of a new type of positron emission tomography with semiconductor detectors (New PET) on an 18F-fluoromisonidazole (FMISO)-guided intensity-modulated radiation therapy (IMRT) plan was investigated by comparing the plan with the use of a state-of-the-art PET/computed tomography system (PET/CT) in nasopharyngeal cancer (NPC) patients. Methods and Materials: Twenty-four patients with non-NPC malignant tumors (control group) and 16 patients with NPC were subjected to FMISO-PET. The threshold of the tumor-to-muscle (T/M) ratio in each PET scan was calculated. The hypoxic volume within the gross tumor volume was determined using each PET ([NewPET]GTVh and [PET/CT]GTVh, respectively). Dose-escalation IMRT plans prescribing 84Gy to each GTVh were carried out. Results: The threshold of the T/M ratio was calculated to be 1.35 for New PET and 1.23 for PET/CT. The mean volume of [NewPET]GTVh was significantly smaller than that of [PET/CT]GTVh (1.5±1.6cc vs. 4.7±4.6cc, respectively, P =0.0020). The dose-escalation IMRT plans using New PET were superior in dose distribution to those using PET/CT. Dose escalation was possible in all 10 New PET-guided plans but not in one PET/CT-guided plan, because the threshold dose to the brainstem was exceeded. Conclusion: New PET was suggested to be useful for accurate dose escalation in FMISO-guided IMRT for patients with NPC.
- 2013-01-01
著者
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Hirano Satoshi
北海道大学 医学研究科腫瘍外科学分野
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Tamaki Nagara
台湾
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Shiga Tohru
Department Of Nuclear Medicine Hokkaido University Graduate School Of Medicine
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Sugiura Hiroshi
Department Of Surgical Oncology Division Of Cancer Medicine Hokkaido University Graduate School Of M
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Nakata Tomoaki
Second Department Of Internal Medicine Sapporo Medicine University
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HIRANO SATOSHI
Department of Surgical Oncology, Hokkaido University Graduate School of Medicine
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Tamaki Nagara
Hokkaido University School Of Medicine Department Of Tracer Kinetics And Department Of Nuclear Medic
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Kuge Yuji
Department Of Tracer Kinetics Hokkaido University School Of Medicine
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Kuge Y
Hokkaido Univ. Sapporo Jpn
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Okamoto Shouzo
Department Of Nuclear Medicine Hokkaido University Graduate School Of Medicine
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Shirato Hiroki
Keiyukai Sapporo Hospital Sapporo Jpn
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Onimaru Rikiya
Division Of Radiation Oncology Department Of Radiology Hokkaido University School Of Medicine
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Katoh Norio
Department Of Radiology Hokkaido University Graduate School Of Medicine
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Kuge Yuji
Central Institute Of Isotope Science Hokkaido University
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Tamaki Nagara
Department Of Nuclear Medicine Hokkaido University School Of Medicine
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Nakata Tomoaki
Department Of Cardiology Sapporo Medical University School Of Medicine
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Shiga Tohru
Hokkaido University Graduate School Of Medicine Department Of Nuclear Medicine
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Tamaki Nagara
Hokkaido University Graduate School Of Medicine Department Of Nuclear Medicine
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Haba Shin
Department Of Gastroenterology Hokkaido University Graduate School Of Medicine
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Hirano Satoshi
Surgical Oncology Hokkaido University Graduate School Of Medicine
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