Quantitative analysis of coronary endothelial function with generator-produced 82Rb PET : comparison with 15O-labelled water PET
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概要
- 論文の詳細を見る
Purpose: Endothelial dysfunction is the earliest abnormality in the development of coronary atherosclerosis. Rubidium-82 (82Rb) is a generator-produced positron emission tomography (PET) myocardial perfusion tracer that is becoming more widely used. We aimed to develop a method for quantitative assessment of coronary endothelial function using the myocardial blood flow (MBF) response during a cold pressor test (CPT) in smokers, measured using 82Rb PET and ii) compare the results with those measured using 15O-water PET. Methods: MBF was assessed at rest and during CPT with 82Rb and 15O-water in 9 controls and 10 smokers. A one-compartment model with tracer extraction correction was used to estimate MBF with both tracers. CPT response was calculated as the ratio of MBF during CPT to MBF at rest. Results: At rest, measurements of MBF for smokers vs. controls were not different using 15O-water (0.86 ± 0.18 vs. 0.70 ± 0.13, p = 0.426) than they were using 82Rb (0.83 ± 0.23 vs. 0.62 ± 0.20, p = 0.051). Both methods showed a reduced CPT response in smokers vs. controls (15O-water, 1.03 ± 0.21 vs. 1.42 ± 0.29, p = 0.006; 82Rb, 1.02 ± 0.28 vs. 1.70 ± 0.52, p < 0.001). There was high reliability [intra-class correlation coefficients: 0.48 (0.07, 0.75)] of MBF measurement between 82Rb and 15O-water during CPT. Conclusions: Using CPT, 82Rb MBF measurements detected coronary endothelial dysfunctions in smokers. 82Rb MBF measurements were comparable to those made using the 15O-water approach. Thus, 82Rb PET may be applicable for risk assessments or evaluation of risk factor modification in subjects with coronary risk factors.
- Springer Berlin / Heidelbergの論文
著者
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Yoshida K
Furukawa City Hospital
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Yoshinaga Kaoru
The Second Department Of Internal Medicine Tohoku University School Of Medicine
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Tamaki Nagara
台湾
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Nakata Tomoaki
札幌医科大学 医学部
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Nakata Tomoaki
Second Department Of Internal Medicine Sapporo Medicine University
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Naya Masanao
Department Of Cardiovascular Medicine Hokkaido University
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Manabe Osamu
Department of Nuclear Medicine, Hokkaido University graduate School of Medicine
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Tamaki Nagara
Hokkaido University School Of Medicine Department Of Tracer Kinetics And Department Of Nuclear Medic
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Katoh C
Department Of Health Science Hokkaido University Graduate School Of Medicine
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Yoshinaga Keiichirou
Department Of Nuclear Medicine Hokkaido University
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Dekemp Rob
Cardiac Pet Centre University Of Ottawa Heart Institute
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Manabe Osamu
Department Of Nuclear Medicine Hokkaido University Graduate School Of Medicine
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Klein Ran
Department Of Nuclear Medicine Hokkaido University Graduate School Of Medicine
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Tamaki Nagara
Hokkaido University Nuclear Medicine
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Yoshinaga Keiichiro
Department Of Nuclear Medicine Hokkaido University
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Yoshinaga Keiichiro
Department Of Photobiology Hokkaido University Graduate School Of Medicine
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Tamaki Nagara
Department Of Nuclear Medicine Hokkaido University School Of Medicine
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Nakata Tomoaki
Department Of Cardiology Sapporo Medical University School Of Medicine
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Tamaki Nagara
Hokkaido University School Of Medicine Department Of Tracer Kinetics And Department Of Nuclear Medic
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Yoshinaga Keiichiro
Department Of Photobiology Division Of Molecular Cellular Imaging Hokkaido University Graduate Schoo
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Tamaki Nagara
Hokkaido University Graduate School Of Medicine Department Of Nuclear Medicine
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